Lithium (orotate) 5 mg by Pure Encapsulations – Mood, Cognitive, and Neurotransmitter Support
Lithium (orotate) 5 mg by Pure Encapsulations is a low-dose lithium supplement that combines 5 mg of lithium with 200 mg of N-acetyl-l-cysteine in a vegetarian capsule. The manufacturer positions this PureSYNAPSE™ formula for emotional wellness support, healthy mood support, and normal behavior in adults.
Lithium participates in signaling cascades associated with cognitive function support and normal neurotransmitter activity. N-acetyl-l-cysteine supplies cysteine for glutathione production, complementing lithium's relationship with antioxidant enzyme support. The defined combination is intended for close professional oversight rather than casual mineral supplementation.
Key Lithium (orotate) 5 mg Benefits
- Provides 5 mg of lithium from lithium orotate.
- Includes 200 mg of free-form N-acetyl-l-cysteine.
- Supports normal mood, memory, behavior, and emotional wellness.
- Promotes signaling pathways involved in brain health and antioxidant defenses.
How Lithium (orotate) 5 mg Works
Lithium (orotate) 5 mg works through a trace amount of lithium that interacts with intracellular signaling and dopamine- and serotonin-mediated pathways. N-acetyl-l-cysteine supplies a precursor used to build glutathione, while manufacturer-cited cellular research connects lithium exposure with glutathione-S-transferase expression. These separate actions place neurotransmitter signaling and redox maintenance within one professionally managed formula.
Key Functional Ingredients Include:
- Lithium: Provides 5 mg from lithium orotate for normal neuronal signaling, mood, and cognitive performance.
- N-Acetyl-L-Cysteine: Provides 200 mg of free-form NAC as a cysteine source for glutathione-related antioxidant pathways.
Lithium (orotate) 5 mg Is Formulated For
- Adults whose health professional recommends low-dose lithium for mood, memory, or behavioral wellness.
- People using a monitored cognitive-support plan that includes lithium and NAC.
- Vegetarian users who can complete the required medication, mood, lithium-level, and kidney-function monitoring.
Supplements support your health but do not replace a balanced diet. Always check with your healthcare practitioner if you have doubts about a new supplement. Or you may book a FREE product consultation with Holistic Health Partners, led by Carolyn Mulally BS, RN, HN-BC. You may also wish to explore our other Mood Support Supplements, Brain Products, and Pure Encapsulations collections.
Recommendation: As a dietary supplement, take 1 capsule daily, with a meal, or as directed by a health professional.
Serving Size: 1 capsule
Servings Per Container: 90
Lithium (as lithium orotate) ... 5 mg
N-Acetyl-L-Cysteine (free-form) ... 200 mg
Other Ingredients: vegetarian capsule (cellulose, water), ascorbyl palmitate, hypoallergenic plant fiber (cellulose).
Does Not Contain: Wheat, soy, dairy, eggs, artificial colors and sweeteners, coatings and shellacs, GMOs, tree nuts, peanuts, sesame, unnecessary binders, fillers and preservatives, magnesium stearate, gluten, trans fat and hydrogenated oils.
Storage: Store in a cool, dry place.
Warnings/Cautions: Not to be taken by pregnant and lactating women. Consult your health professional before using this product. Not to be taken in conjunction with antidepressants unless advised by a health professional. Individuals with bipolar disorder and depression must be monitored closely by a health professional if taking this supplement. It is recommended that individuals taking this supplement have lithium levels and kidney function monitored regularly. Do not exceed the dose recommended by your health professional.
Frequently Asked Questions About Lithium (orotate) 5 mg
What are the benefits of Lithium (orotate) 5 mg?
Lithium (orotate) 5 mg benefits adults by pairing a trace mineral used in neuronal signaling with 200 mg of N-acetyl-l-cysteine. Lithium can influence dopamine- and serotonin-mediated processes as well as intracellular messenger systems related to mood, memory, and behavior. NAC contributes cysteine, the limiting substrate cells often use when assembling glutathione. Pure Encapsulations also cites laboratory evidence connecting lithium with expression of glutathione-S-transferase, an enzyme involved in cellular defense. The pairing therefore addresses signaling and antioxidant biochemistry through different constituents rather than simply raising the mineral amount. A single capsule provides clearly stated quantities of both actives, which supports careful exposure tracking. Those features are meaningful only within clinical monitoring because lithium has a narrow safety context and should not be treated like an ordinary over-the-counter mineral.
Who should take Lithium (orotate) 5 mg?
Lithium (orotate) 5 mg is meant for adults whose clinician has identified a specific reason to use low-dose lithium alongside NAC for emotional, behavioral, memory, or cognitive wellness. Suitable selection requires a review of antidepressants, psychiatric history, hydration, sodium balance, renal function, and all other sources of lithium. The label specifically requires close supervision for individuals with bipolar disorder or depression and regular checks of both lithium levels and kidney performance. Pregnant and lactating women must not take the product. A person using an antidepressant should not add it unless the prescriber approves the combination. NAC may also be relevant to the clinician's plan when glutathione precursor support is desired. This monitoring burden makes self-selection inappropriate even though each capsule contains a nutritionally small mineral quantity.
Are there any side effects of taking Lithium (orotate) 5 mg?
Lithium (orotate) 5 mg can produce thirst, tremor, nausea, diarrhea, weakness, drowsiness, coordination changes, or increased urination, and unexpected symptoms require prompt assessment. Dehydration, major changes in salt intake, kidney impairment, and interacting medicines can alter lithium handling. Not to be taken by pregnant and lactating women. Consult your health professional before using this product. Not to be taken in conjunction with antidepressants unless advised by a health professional. Individuals with bipolar disorder and depression must be monitored closely by a health professional if taking this supplement. It is recommended that individuals taking this supplement have lithium levels and kidney function monitored regularly. Do not exceed the dose recommended by your health professional. Severe confusion, vomiting, slurred speech, marked shaking, or poor balance warrants urgent medical attention rather than another capsule.
How does Lithium (orotate) 5 mg support overall health?
Lithium (orotate) 5 mg supports overall health through cellular communication in the nervous system and through NAC-dependent glutathione synthesis. Lithium ions can modify enzyme activity and second-messenger pathways that sit downstream from neurotransmitter receptors, creating a biochemical route to normal mood and behavioral regulation. Researchers have also examined lithium's relationship with brain-derived neurotrophic factor, a protein involved in neuronal maintenance and adaptation. NAC is converted to cysteine after absorption and can replenish material needed for glutathione, which helps cells manage reactive compounds. Combining the two does not remove the need for sleep, adequate protein, stable hydration, or medical management of psychiatric symptoms. Instead, the formula supplies two defined inputs whose effects and tolerability can be followed with laboratory testing, medication review, and direct observation of cognitive or mood changes.
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

