Avipaxin 90c by NeuroScience
Contains ingredients involved in the synthesis and activity of acetylcholine, a neurotransmitter important for attention, learning, memory, and downregulation of the immune response*
Acetylcholine is a neurotransmitter found throughout the peripheral and central nervous systems and is well known for its importance in muscle contraction, attention, learning, memory, and stress (1). Acetylcholine released by the vagus nerve is essential to immune health due to its ability to downregulate cytokine expression in the spleen, liver, and gastrointestinal tract (2).
Key ingredients
Acetyl-L-carnitine: Derivative of L-carnitine shown to increase plasma and brain levels of L-carnitine (3, 4). L-carnitine facilitates energy production in mitochondria (5) and provides antioxidant protection through its ability to scavenge reactive oxygen species and metal ions (6).* Provides an acetyl group required for acetylcholine synthesis (7).*
Choline bitartrate: Choline donor (8) and precursor to acetylcholine (9). Choline is an essential nutrient important for cell health, methylation and lipid metabolism (10).*
AlphaSize?« (Alpha-glycerylphosphorylcholine): Patented choline donor (11) and precursor to acetylcholine (9).
Huperzia Serrata aerial parts (standardized to 1% to huperzine A): Potent and selective inhibitor of acetylcholinesterase (AChE), an enzyme that breaks down acetylcholine in the synapse (12).*
References
1. Ferreira-Vieira T, et al. Curr Neuropharmacol. 2016;14(1):101-15.
2. Tracey K. Nat Rev Immunol. 2009;9(6):418-28.
3. Parnetti L, et al. Eur J Clin Pharmacol. 1992;42(1):89-93.
4. Rebouche C. Ann N Y Acad Sci. 2004;1033:30-41.
5. Pekala J, et al. Curr Drug Metab. 2011;12(7):667-78.
6. Gulcin I. Life Sci. 2006;78(8):803-11.
7. White H and Scates P. Neurochem Res. 1990;15(6):597-601.
8. Wallace J, et al. Br J Nutr. 2012;108(7):1264-71.
9. Ueland P. J Inherit Metab Dis. 2011;34(1):3-15.
10. Zeisel S. Nutrition. 2000;16(7-8):669-71.
11. Abbiati G, et al. Eur J Drug Metab Pharmacokinet. 1993;18(2):173-80.
12. Tun M and Herzon S. J Exp Pharmacol. 2012;4:113-23.
Recommended Use:
Take 1-2 capsules one to two times daily or as directed by your healthcare provider.
If you are pregnant or nursing, consult your healthcare provider before use.
Serving Size: 3 Capsules
Serving per Container: 30
Amount per Serving:
Proprietary Blend ... 1.82g
Acetyl-L-carnitine HCl, Alpha-glycerylphosphorylcholine (50% alpha-GPC), and Huperzia serrata aerial parts (standardized to 1% huperzine A).
Other Ingredients: Vegetable capsule (Hypromellose, water), Microcrystalline cellulose, Magnesium stearate (vegetable source), and Silica.
Contains: Lecithin from soy.
If you are pregnant or nursing, consult your healthcare provider before use.