Similase by Integrative Therapeutics – Meal Digestion Support with Digestive Enzymes
Similase capsules by Integrative Therapeutics provide digestive enzyme support with a blend of microbial enzymes for mixed meals. This vegan formula combines enzymes that act on proteins, carbohydrates, fats, and plant fiber rather than focusing on just one food component.
Different foods require different digestive steps. Similase brings several enzyme activities together in a plant-derived capsule, with activity measurements listed for each enzyme group.
Key Similase Benefits
- Supports the breakdown of dietary proteins into smaller components through a combination of microbial proteases.
- Helps digest starches and specific sugars using complementary enzymes rather than a single carbohydrate-focused ingredient.
- Supports fat digestion with lipases that act on the fats present in mixed meals.
- Provides cellulase activity to help break down cellulose, a structural component of plant-based foods.
How Similase Works
Enzymes help split food molecules into smaller pieces. Each enzyme recognizes particular food components: proteases work on protein, amylase works on starch, and lipase works on fat. Similase also includes lactase for milk sugar, sucrase for sucrose, cellulase for cellulose, and phytase for phytate. These distinct activities explain why the formula combines multiple enzymes.
The formula is intended for use with meals, when the enzymes can encounter the food components they help break down.
Key Functional Ingredients Include:
- Protease I, II, III, IV: Support protein digestion by breaking bonds within food proteins, producing smaller peptides and amino acids. This is a digestive step that makes larger protein molecules easier to process, rather than adding extra protein to the meal.
- Amylase: Supports carbohydrate digestion by breaking starch into smaller carbohydrate fragments. Starches occur in foods such as grains and potatoes; amylase addresses this type of carbohydrate rather than performing the jobs of lactase or sucrase.
- Lactase I, II: Support lactose digestion by splitting the milk sugar lactose into glucose and galactose. The manufacturer identifies the lactase source as Aspergillus oryzae, not milk. Lactase acts on a sugar; it does not remove milk proteins or make dairy appropriate for someone with milk allergy.
- Lipase I, II: Support fat digestion by breaking dietary fats into smaller components. This complements the protein- and carbohydrate-digesting enzymes in meals containing several types of nutrients; it does not block fat absorption or establish a weight-management benefit.
- Cellulase I, II: Provide fiber digestion support by breaking down cellulose, a structural material in plant cell walls. Cellulase has a different target from amylase, which acts on starch. It does not replace dietary fiber or make all types of fiber digestible.
Similase Is Formulated For
- Adults looking for a broad enzyme blend to accompany meals containing protein, starches, sugars, fats, and plant foods.
- Adults who prefer a vegan capsule formula containing no dairy, artificial colors, or flavors.
Supplements support your health but do not replace a balanced diet. Always check with your healthcare practitioner if you have doubts about a new supplement. Or you may book a FREE product consultation with Holistic Health Partners, led by Carolyn Mulally BS, RN, HN-BC. You may also wish to explore our other GI Digestion/Enzyme Supplements, GI Health Supplements, and Integrative Therapeutics Supplements and Vitamins collections.
Recommendation: Adults take 2 capsules at the beginning of each meal, up to 3 times daily, or as recommended by a healthcare professional.
Serving Size: 2 Capsules
Servings Per Container: 90-capsule bottle: 45; 180-capsule bottle: 90
Microbial Enzymes ... 563 mg**
Assay Method
Protease I, II, III, IV
FCC (pH 4.7) ... 82,000 HUT
FCC (pH 7.0) ... 56,653 PC
USP (pH 7.5) ... 31,394 USP
Amylase
FCC (pH 4.6) ... 31,932 DP°
FCC (pH 4.8) ... 31,932 DU
USP (pH 6.8) ... 21,288 USP
Lactase I, II
FCC (pH 4.5) ... 1,600 ALU
Lipase I, II
FCC (pH 7.0) ... 2,200 FIP
Cellulase I, II
FCC (pH 4.5) ... 350 CU
Sucrase (Invertase)
FCC (pH 4.5) ... 936 SU
Phytase
FCC (pH 5.5) ... 1.7 FTU
**Daily Value (DV) not established.
Other Ingredients: plant-derived capsule (hypromellose), cellulose, magnesium stearate
Does Not Contain: Contains no dairy, or artificial colors or flavors.
Storage: Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.
Additional product caution: Not recommended for use if peptic ulcer, gastritis, or heartburn is present.
Frequently Asked Questions About Similase
What are the benefits of Similase?
Similase supports digestion of several components of a mixed meal rather than targeting just one nutrient. Proteases break down protein, amylase works on starch, lipases act on fats, and lactase breaks down lactose. Cellulases add support for breaking down cellulose in plant foods. These complementary microbial enzymes act on different food components, giving the blend a broader digestive focus than a lactase-only supplement. The formula contains no dairy, artificial colors, or flavors.
Who should take Similase?
Similase is intended for adults seeking digestive enzyme support with meals. It may suit someone looking for a vegan capsule that combines protein-, carbohydrate-, fat-, and fiber-digesting enzymes. The blend includes lactase for milk sugar and cellulase for cellulose in plant foods, alongside enzymes for other meal components. People who are pregnant, nursing, have diabetes, or take medications should consult a healthcare professional before use.
Are there any side effects of taking Similase?
Similase is not appropriate for everyone. If you are pregnant, nursing, have diabetes, or if you are taking any medications, consult a healthcare professional before use. Not recommended for use if peptic ulcer, gastritis, or heartburn is present. The lactase acts on milk sugar, not milk proteins, so it does not make dairy suitable for milk allergy. Keep out of reach of children. Safety sealed with inner seal. Do not use if seal is broken or missing. Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.
How does Similase support overall health?
Similase supports overall nutrition by assisting the digestive breakdown of food components before they can be used by the body. Its complementary enzymes have different targets, so protein, starch, fat, lactose, and cellulose are not all handled by the same enzyme. This is digestive support, not a source of replacement dietary protein, vitamins, or minerals. Choosing meals that meet your nutritional needs remains important. Its lactase works on milk sugar rather than milk proteins, so digestive support should not be confused with protection from milk allergy.
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

