NorLox Ultra 60c

Contains ingredients important for the management of joint aches*

Key ingredients

Boswellia serrata (70% total boswellic acids): Leukotrienes are immune mediators that induce and sustain immune activation (1). Boswellic acids are shown to inhibit 5-lipoxygenase (5-LOX), an enzyme responsible for the synthesis of immunostimulatory molecules called leukotrienes (2, 3).* In a randomized, double-blind, placebo-controlled, crossover study, Boswellia serrata significantly improved the threshold and tolerance to musculoskeletal discomfort (4).*

Curcuma longa (Turmeric) (95% curcuminoids): Botanical shown to lower levels of TNF- and IL-6 (5).* TNF- and IL-6 are cytokines that play an important role in regulating the immune response and joint discomfort (6, 7). Elevated levels of TNF- and IL-6 in joint fluid have been correlated with increased joint discomfort (8, 9).

L-cysteine: Precursor to glutathione (10).* Glutathione provides antioxidant protection and detoxification properties (10).

5-HTP (from Griffonia simplicifolia seed extract): 5-hydroxytryptophan (5-HTP) crosses the blood-brain barrier and is a precursor to serotonin and melatonin (11).* Serotonin plays an important role in processing and inhibiting pain signaling by the central nervous system (12).

References

1. Gennara A and Haeggstrom J. Adv Immunol. 2012;116:51-92.

2. Schweizer S, et al. J Nat Prod. 2000;63:1058-61.

3. Radmark O, et al. Biochim Biophys Acta. 2015;1851(4):331-9.

4. Prabhavathi K, et al. Indian J Pharmacol. 2014;46(5):475-9.

5. Usharani P, et al. Drugs R D. 2008;9(4):243-50.

6. Holdsworth S and Gan P. Clin J Am Soc Nephrol. 2015;10(12):2243-54.

7. Miller R, et al. Cytokine. 2014;70(2):185-93.

8. Orita S, et al. BMC Musculoskelet Disord. 2011;12:144.

9. Cuellar J, et al. J Bone Joint Surg Am. 2009;91(10):2313-20.

10. Rushworth G and Megson I. Pharmacol Ther. 2014;141(2):150-9.

11. Shaw K, et al. Cochrane Database Syst Rev. 2002;(1):CD003198.

12. Bardin L. Behav Pharmacol. 2011;22(5-6):390-404.

Recommendation:

Take 2 capsules one to two times daily or as directed by your healthcare provider.

If you are pregnant or nursing, consult your healthcare provider before use.

Serving Size: 2 Capsules?á?á

Servings Per Container: 30?á

Amount Per Serving:

Amount Per Serving

Boswellia serrata gum extract ... 400mg

(70% total boswellic acids)

Curcuma longa rhizome extract ... 400mg

(Turmeric)(95% curcuminoids)

L-cysteine ... 250mg

5-hydroxytryptophan ... 20mg

(from Griffonia simplicifolia seed extract)

Other Ingredients: Vegetable capsule (Hypromellose, water), Microcrystalline cellulose, Magnesium stearate (vegetable source), and Silicon dioxide.