{"num_reviews":0,"url":"https://covenanthealthproducts.com/nac-xymogen/","add_this":[{"service":"facebook","annotation":""},{"service":"twitter","annotation":""},{"service":"linkedin","annotation":""}],"gtin":null,"brand":{"name":"Xymogen","url":"https://covenanthealthproducts.com/xymogen/"},"id":18023,"can_purchase":true,"meta_description":"N-Acetyl-L-Cysteine (NAC) by Xymogen supports glutathione production, antioxidant defenses, detox pathways, and overall cellular health.","category":["Brands/Xymogen Professional Formulas Supplements","Brands/Xymogen"],"AddThisServiceButtonMeta":"","main_image":{"data":"https://cdn11.bigcommerce.com/s-35tuw7jhw2/images/stencil/{:size}/products/18023/39084/NAC-60c-Xymogen_47_11zon__25317.1742323588.jpg?c=1","alt":"NAC 60 C by Xymogen"},"add_to_wishlist_url":"/wishlist.php?action=add&product_id=18023","shipping":{"calculated":true},"custom_fields":[{"id":"150570","name":"Brand","value":"<a href='/brands/xymogen-professional-formulas/'><img src=https://cdn11.bigcommerce.com/s-35tuw7jhw2/product_images/uploaded_images/brand-logos/xymogen_278x90.png\" width=\"278\" height=\"90\"></a>"},{"id":"150571","name":"Questions","value":"<a href='/complimentary-product-consultation/'><img src=https://cdn11.bigcommerce.com/s-35tuw7jhw2/product_images/uploaded_images/need_someone_to_talk_to_250px.png\"></a><div><a href=\"/need-product-help\">Talk to an Expert</a></div>"}],"sku":"XY-NAC","description":"<h2>N-Acetyl-L-Cysteine (NAC) by Xymogen &ndash; Antioxidant &amp; Glutathione Support Supplement</h2>\n<p data-start=\"109\" data-end=\"465\"><strong data-start=\"109\" data-end=\"125\">N-Acetyl-L-Cysteine (NAC) by Xymogen</strong> is a high-purity amino acid supplement designed to support the body&rsquo;s natural <strong>antioxidant</strong> defenses and<strong> detoxification</strong> pathways. This clinically trusted <strong data-start=\"321\" data-end=\"355\">N-Acetyl-L-Cysteine supplement</strong> helps promote <strong data-start=\"370\" data-end=\"393\">glutathione support</strong>, cellular resilience, and overall wellness with excellent tolerability.</p>\n<h3 data-start=\"467\" data-end=\"485\">Key N-Acetyl-L-Cysteine (NAC) Benefits</h3>\n<ul>\n<li data-start=\"488\" data-end=\"546\">Supports <strong data-start=\"497\" data-end=\"520\">glutathione support</strong> for cellular protection</li>\n<li data-start=\"549\" data-end=\"628\">Promotes <strong data-start=\"558\" data-end=\"592\">antioxidant support supplement</strong> activity against oxidative stress</li>\n<li data-start=\"631\" data-end=\"699\">Encourages <strong data-start=\"642\" data-end=\"665\">liver detox support</strong> and healthy metabolic processes</li>\n<li data-start=\"702\" data-end=\"773\">Helps maintain connective tissue integrity for skin and joint comfort</li>\n<li data-start=\"776\" data-end=\"843\">Supports overall wellness, including <strong data-start=\"813\" data-end=\"843\">respiratory health support</strong></li>\n</ul>\n<h3 data-start=\"845\" data-end=\"1273\">How N-Acetyl-L-Cysteine (NAC) Works</h3>\n<p><a title=\"N-Acetylcysteine (NAC): Impacts on Human Health\" href=\"https://pmc.ncbi.nlm.nih.gov/articles/PMC8234027/\" target=\"_blank\" rel=\"noopener\"><strong>N-Acetyl-L-Cysteine</strong></a> serves as a direct precursor to glutathione, one of the body&rsquo;s most important endogenous antioxidants. By replenishing cysteine levels, this <strong data-start=\"1029\" data-end=\"1044\">Xymogen NAC</strong> formula helps neutralize free radicals, supports detoxification enzymes, and assists normal inflammatory balance. The simple, <strong>hypoallergenic formulation</strong> is designed for <strong>daily use</strong> with <strong>minimal side effects</strong> when taken as directed.</p>\n<h3 data-start=\"1275\" data-end=\"1308\">Who Should Use N-Acetyl-L-Cysteine (NAC)</h3>\n<ul>\n<li data-start=\"1311\" data-end=\"1384\">Individuals seeking daily <strong data-start=\"1337\" data-end=\"1371\">antioxidant support supplement</strong> protection</li>\n<li data-start=\"1387\" data-end=\"1447\">Those supporting healthy <strong>detoxification</strong> and <strong>liver function</strong></li>\n<li data-start=\"1450\" data-end=\"1524\">Adults focused on maintaining skin vitality and connective tissue health</li>\n<li data-start=\"1527\" data-end=\"1629\">People looking for a gentle, research-driven option to support<strong> joint</strong>, <strong>bone</strong>, and<strong> skin</strong> wellness safely</li>\n</ul>\n<p><strong>Supplements support your health but do not replace a balanced diet</strong>. Always check with your healthcare practitioner if you have doubts about a new supplement. Or you may book a <a title=\"Complimentary Product Consultation\" href=\"https://covenanthealthproducts.com/complimentary-product-consultation/\" target=\"_blank\" rel=\"noopener\"><strong>FREE product consultation</strong></a> with Holistic Health Partners. You may want to look at our other <a title=\"Amino Acids Supplements\" href=\"https://covenanthealthproducts.com/clinic-recommended-products/amino-acids-supplements/\" target=\"_blank\" rel=\"noopener\"><strong>Amino Acid </strong></a>and <a title=\"Anti-Oxidants Supplements\" href=\"https://covenanthealthproducts.com/clinic-recommended-products/anti-oxidants/\" target=\"_blank\" rel=\"noopener\"><strong>Anti-Oxidant</strong></a> products.</p>\n<p data-start=\"2953\" data-end=\"3074\"><strong data-start=\"2953\" data-end=\"2972\">Recommendation:</strong> Take one to two capsules twice daily between meals, or as directed by your healthcare practitioner.</p>\n<p data-start=\"3076\" data-end=\"3145\"><strong data-start=\"3076\" data-end=\"3093\">Serving Size:</strong> 2 Capsules<br data-start=\"3104\" data-end=\"3107\" /><strong data-start=\"3107\" data-end=\"3134\">Servings Per Container:</strong> 30 or 60</p>\n<p data-start=\"3147\" data-end=\"3204\"><strong data-start=\"3147\" data-end=\"3170\">Amount Per Serving:</strong><br data-start=\"3170\" data-end=\"3173\" />N-Acetyl-L-Cysteine 1.2 g</p>\n<p data-start=\"3206\" data-end=\"3292\"><strong data-start=\"3206\" data-end=\"3228\">Other Ingredients:</strong> HPMC (capsule), stearic acid, magnesium stearate, and silica.</p>\n<p data-start=\"3294\" data-end=\"3551\"><strong data-start=\"3294\" data-end=\"3315\">Does Not Contain:</strong> Wheat, gluten, corn, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.</p>\n<p data-start=\"3553\" data-end=\"3707\"><strong data-start=\"3553\" data-end=\"3565\">Caution:</strong> Individuals taking medication should discuss potential interactions with their healthcare practitioner. Do not use if tamper seal is damaged.</p>\n<p data-start=\"3709\" data-end=\"3780\"><strong data-start=\"3709\" data-end=\"3721\">Storage:</strong> Keep closed in a cool, dry place out of reach of children.</p>\n<p data-start=\"3782\" data-end=\"3917\" data-is-last-node=\"\" data-is-only-node=\"\"><em>These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.</em></p>\n<p><img src=\"../../../../product_images/uploaded_images/pdf20logo-sm.png\" alt=\"\" border=\"0px\" /><a href=\"../../../../content/nac-rvdrs.pdf\" target=\"_blank\" rel=\"noopener\"> Click here to view Data Sheet</a></p>\n<hr />\n<p><small> LEGAL NOTICE: Xymogen's Exclusive Professional Formulas are available through select licensed health care professionals. The Internet Sale and Discounting of XYMOGEN formulas are strictly prohibited. covenanthealthproducts.com makes XYMOGEN formulas available only to patients of our clinic. If you are a patient of covenanthealthproducts.com, you may inquire about XYMOGEN by calling (800) 627-6518 </small></p>\n<p><strong>References:</strong></p>\n<ol>\n<li>Krinsky, D. L., LaValle, J. B., Hawkins, E. B., &amp; et al. (2003). <em>Natural therapeutics </em><em>pocket guide</em> (2nd ed.). Lexi-Comp.</li>\n<li>Grandjean, E. M., Berthet, P., Ruffmann, R., &amp; Leuenberger, P. (2000). Efficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: A meta-analysis of published double-blind, placebo-controlled clinical trials. <em>Clinical Therapeutics</em>, 22(2), 209-221. https://doi.org/10.1016/S0149-2918(00)80005-5</li>\n<li>Yal&ccedil;in, E., Altin, F., Cinh&uuml;seyinoglu, F., &amp; et al. (2002). N-acetylcysteine in chronic blepharitis. <em>Cornea</em>, 21(2), 164-168. https://doi.org/10.1097/00003226-200203000-00009</li>\n<li>Ottenwalder, H., &amp; Simon, P. (1987). Differential effect of N-acetylcysteine on excretion of the metals Hg, Cd, Pb and Au. <em>Archives of Toxicology</em>, 60(5), 401-402. https://doi.org/10.1007/BF00314782</li>\n<li>Keogh, J. P., Steffen, B., &amp; Siegers, C. P. (1994). Cytotoxicity of heavy metals in the human small intestinal epithelial cell line I-407: The role of glutathione. <em>Journal of Toxicology and Environmental Health</em>, 43(3), 351-359. https://doi.org/10.1080/009841094160956</li>\n<li>Witschi, A., &amp; et al. (1992). The systemic availability of oral glutathione. <em>European Journal of Clinical Pharmacology</em>, 43, 667-669. https://doi.org/10.1007/BF00187204</li>\n<li>De Rosa, S. C., &amp; et al. (2000). N-acetylcysteine replenishes glutathione in HIV infection. <em>European Journal of Clinical Investigation</em>, 30(10), 841-842. https://doi.org/10.1046/j.1365-2362.2000.00799.x</li>\n<li>Atkuri, K. R., Mantovani, J. J., Herzenberg, L. A., &amp; et al. (2007). N-Acetylcysteine&mdash;a safe antidote for cysteine/glutathione deficiency. <em>Current Opinion in Pharmacology</em>, 7(4), 355-359. https://doi.org/10.1016/j.coph.2007.05.001</li>\n<li>White, A.C., Thannickal, V.J., &amp; Fanburg, B.L.(1994). Glutathione deficiency in human disease.<em>Journal of Nutritional Biochemistry</em>, 5, 218-226.http://www.sciencedirect.com/science/article/pii/0955286394900396</li>\n<li>Pace, G.W., &amp; Leaf C.D.(1995). The role of oxidative stress in HIV disease.<em>Free Radical Biology and Medicine</em>, 19, 523-528.http://doi.org/10.1016/0891-5849(95)00053-A</li>\n<li>Favier, A., Sappey, C., Leclerc, P., &amp; et al.(1994). Antioxidant status and lipid peroxidation in patients infected with HIV.<em>Chemical Biology Interactions</em>, 91(2-3),165-180.http://doi.org/10.1016/0009-2797(94)90092-X</li>\n<li>Nakamura, H., Masutani, H., &amp; Yodoi J.(2002). Redox imbalance and its control in HIV infection.<em>Antioxidants and Redox Signaling</em>, 4(3),455-464.http://doi.org/10.1089/152308602320263580</li>\n</ol>\n<p>13.Roberts R.L., Aroda V.R., Ank B.J.(1995). N-acetylcysteine enhances antibody-dependent cellular toxicity in neutrophils and mononuclear cells from healthy adults and human immunodeficiency virus-infected patients.<em>Journal of Infectious Diseases</em>,172(6),1492-1502.http://doi.org/10.1093/infdis/172.6.1492</p>\n<p>14.Hu H.L., Forsey R.J., Blades T.J., &amp; et al.(2000). Antioxidants may contribute in the fight against ageing: An in vitro model.<em>Mechanisms of Ageing and Development</em>,121(1-3),217-230.http://doi.org/10.1016/S0047-6374(00)00155-X</p>","tags":[],"warranty":"","price":{"without_tax":{"formatted":"$35.99","value":35.99,"currency":"USD"},"tax_label":"Tax"},"detail_messages":"","availability":"Usually Ships in 48 to 72 Hours","page_title":"NAC | Xymogen","cart_url":"https://covenanthealthproducts.com/cart.php","max_purchase_quantity":0,"mpn":"300001010","upc":"871149000011","options":[{"id":46724,"type":"Configurable_PickList_Set","display_name":"Size","required":true,"state":"variant_option","partial":"set-rectangle","condition":true,"values":[{"id":160269,"label":"60 CT","selected":true,"data":"60 CT"},{"id":160270,"label":"120 CT","selected":false,"data":"120 CT"}]},{"id":36845,"type":"Configurable_PickList_Set","display_name":"Recurring Order","required":true,"state":"modifier","partial":"set-select","condition":true,"values":[{"id":48845,"label":"One Time Purchase","selected":true,"data":"One Time Purchase"},{"id":48846,"label":"Every 20 Days","selected":false,"data":"Every 20 Days"},{"id":48847,"label":"Every 30 Days","selected":false,"data":"Every 30 Days"},{"id":48848,"label":"Every 40 Days","selected":false,"data":"Every 40 Days"},{"id":159647,"label":"Every 45 Days","selected":false,"data":"Every 45 Days"},{"id":48849,"label":"Every 60 Days","selected":false,"data":"Every 60 Days"},{"id":48850,"label":"Every 90 Days","selected":false,"data":"Every 90 Days"},{"id":48851,"label":"Every 120 Days","selected":false,"data":"Every 120 Days"},{"id":48852,"label":"Every 180 Days","selected":false,"data":"Every 180 Days"}]}],"related_products":[{"id":22521,"sku":"ARG-N-ACE","name":"N-Acetyl L- Cysteine (NAC) 120t","url":"https://covenanthealthproducts.com/n-acetyl-cysteine-nac-120-tablets-by-allergy-research-group","availability":"Usually Ships in 48 to 72 Hours","rating":0,"brand":{"name":"Allergy Research Group"},"category":["Brands/Allergy Research Group Supplements and Vitamins"],"summary":"\nN-Acetyl L-Cysteine (NAC) 120t by Allergy Research Group\nN-Acetyl L-Cysteine (NAC) by Allergy Research Group is a free form amino acid supplement that provides a natural source of sulfur for...","image":{"data":"https://cdn11.bigcommerce.com/s-35tuw7jhw2/images/stencil/{:size}/products/22521/36735/NAC_N-Acetyl-L-Cysteine_Glutathione_Precursor_120t_Allergy_Research__81352.1738525735.jpg?c=1","alt":"N-Acetyl L-Cysteine (NAC) 120t by Allergy Research Group"},"images":[{"data":"https://cdn11.bigcommerce.com/s-35tuw7jhw2/images/stencil/{:size}/products/22521/36735/NAC_N-Acetyl-L-Cysteine_Glutathione_Precursor_120t_Allergy_Research__81352.1738525735.jpg?c=1","alt":"N-Acetyl L-Cysteine (NAC) 120t by Allergy Research Group"}],"date_added":"Dec 06, 2021","pre_order":false,"show_cart_action":true,"has_options":true,"stock_level":null,"low_stock_level":null,"qty_in_cart":0,"custom_fields":[{"id":127196,"name":"Brand","value":"<a href='/brands/allergy-research-group/'><img src=https://cdn11.bigcommerce.com/s-35tuw7jhw2/product_images/uploaded_images/brand-logos/allergy-research-group_278x90.png\" width=\"278\" height=\"90\"></a>"},{"id":127197,"name":"Questions","value":"<a href='/complimentary-product-consultation/'><img src=https://cdn11.bigcommerce.com/s-35tuw7jhw2/product_images/uploaded_images/need_someone_to_talk_to_250px.png\"></a><div><a href=\"/need-product-help\">Talk to an Expert</a></div>"}],"num_reviews":0,"weight":{"formatted":"0.00 Ounces","value":0},"demo":false,"show_quantity_on_backorder":true,"show_quantity_on_hand":true,"show_backorder_message":true,"show_backorder_availability_prompt":true,"backorder_availability_prompt":"More available for backorder","price":{"without_tax":{"currency":"USD","formatted":"$40.99","value":40.99},"tax_label":"Tax"},"add_to_wishlist_url":"/wishlist.php?action=add&product_id=22521"}],"shipping_messages":[],"rating":0,"reviews":{"messages":[],"captcha":"6LdWf8gSAAAAAI83aRectJhbwidegZKk8PzWBltH","total":0,"show_review_email":true,"recaptcha":{"enabled":1,"public_key":"6LdWf8gSAAAAAI83aRectJhbwidegZKk8PzWBltH","markup":"<div class=\"g-recaptcha\" data-sitekey=\"6LcjX0sbAAAAACp92-MNpx66FT4pbIWh-FTDmkkz\"></div><br/>"}},"bulk_discount_rates":[],"meta_keywords":"","show_quantity_input":1,"title":"NAC","gift_wrapping_available":false,"min_purchase_quantity":1,"customizations":[],"images":[{"data":"https://cdn11.bigcommerce.com/s-35tuw7jhw2/images/stencil/{:size}/products/18023/39084/NAC-60c-Xymogen_47_11zon__25317.1742323588.jpg?c=1","alt":"NAC 60 C by Xymogen"},{"data":"https://cdn11.bigcommerce.com/s-35tuw7jhw2/images/stencil/{:size}/products/18023/47585/NAC_60_C_by_Xymogen_Label__33798.1765554082.png?c=1","alt":"NAC 60 C by Xymogen Label"}]}

NAC

Xymogen

$35.99
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XY-NAC
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871149000011
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N-Acetyl-L-Cysteine (NAC) by Xymogen – Antioxidant & Glutathione Support Supplement

N-Acetyl-L-Cysteine (NAC) by Xymogen is a high-purity amino acid supplement designed to support the body’s natural antioxidant defenses and detoxification pathways. This clinically trusted N-Acetyl-L-Cysteine supplement helps promote glutathione support, cellular resilience, and overall wellness with excellent tolerability.

Key N-Acetyl-L-Cysteine (NAC) Benefits

  • Supports glutathione support for cellular protection
  • Promotes antioxidant support supplement activity against oxidative stress
  • Encourages liver detox support and healthy metabolic processes
  • Helps maintain connective tissue integrity for skin and joint comfort
  • Supports overall wellness, including respiratory health support

How N-Acetyl-L-Cysteine (NAC) Works

N-Acetyl-L-Cysteine serves as a direct precursor to glutathione, one of the body’s most important endogenous antioxidants. By replenishing cysteine levels, this Xymogen NAC formula helps neutralize free radicals, supports detoxification enzymes, and assists normal inflammatory balance. The simple, hypoallergenic formulation is designed for daily use with minimal side effects when taken as directed.

Who Should Use N-Acetyl-L-Cysteine (NAC)

  • Individuals seeking daily antioxidant support supplement protection
  • Those supporting healthy detoxification and liver function
  • Adults focused on maintaining skin vitality and connective tissue health
  • People looking for a gentle, research-driven option to support joint, bone, and skin wellness safely

Supplements support your health but do not replace a balanced diet. Always check with your healthcare practitioner if you have doubts about a new supplement. Or you may book a FREE product consultation with Holistic Health Partners. You may want to look at our other Amino Acid and Anti-Oxidant products.

Recommendation: Take one to two capsules twice daily between meals, or as directed by your healthcare practitioner.

Serving Size: 2 Capsules
Servings Per Container: 30 or 60

Amount Per Serving:
N-Acetyl-L-Cysteine 1.2 g

Other Ingredients: HPMC (capsule), stearic acid, magnesium stearate, and silica.

Does Not Contain: Wheat, gluten, corn, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

Caution: Individuals taking medication should discuss potential interactions with their healthcare practitioner. Do not use if tamper seal is damaged.

Storage: Keep closed in a cool, dry place out of reach of children.

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Click here to view Data Sheet


LEGAL NOTICE: Xymogen's Exclusive Professional Formulas are available through select licensed health care professionals. The Internet Sale and Discounting of XYMOGEN formulas are strictly prohibited. covenanthealthproducts.com makes XYMOGEN formulas available only to patients of our clinic. If you are a patient of covenanthealthproducts.com, you may inquire about XYMOGEN by calling (800) 627-6518

References:

  1. Krinsky, D. L., LaValle, J. B., Hawkins, E. B., & et al. (2003). Natural therapeutics pocket guide (2nd ed.). Lexi-Comp.
  2. Grandjean, E. M., Berthet, P., Ruffmann, R., & Leuenberger, P. (2000). Efficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: A meta-analysis of published double-blind, placebo-controlled clinical trials. Clinical Therapeutics, 22(2), 209-221. https://doi.org/10.1016/S0149-2918(00)80005-5
  3. Yalçin, E., Altin, F., Cinhüseyinoglu, F., & et al. (2002). N-acetylcysteine in chronic blepharitis. Cornea, 21(2), 164-168. https://doi.org/10.1097/00003226-200203000-00009
  4. Ottenwalder, H., & Simon, P. (1987). Differential effect of N-acetylcysteine on excretion of the metals Hg, Cd, Pb and Au. Archives of Toxicology, 60(5), 401-402. https://doi.org/10.1007/BF00314782
  5. Keogh, J. P., Steffen, B., & Siegers, C. P. (1994). Cytotoxicity of heavy metals in the human small intestinal epithelial cell line I-407: The role of glutathione. Journal of Toxicology and Environmental Health, 43(3), 351-359. https://doi.org/10.1080/009841094160956
  6. Witschi, A., & et al. (1992). The systemic availability of oral glutathione. European Journal of Clinical Pharmacology, 43, 667-669. https://doi.org/10.1007/BF00187204
  7. De Rosa, S. C., & et al. (2000). N-acetylcysteine replenishes glutathione in HIV infection. European Journal of Clinical Investigation, 30(10), 841-842. https://doi.org/10.1046/j.1365-2362.2000.00799.x
  8. Atkuri, K. R., Mantovani, J. J., Herzenberg, L. A., & et al. (2007). N-Acetylcysteine—a safe antidote for cysteine/glutathione deficiency. Current Opinion in Pharmacology, 7(4), 355-359. https://doi.org/10.1016/j.coph.2007.05.001
  9. White, A.C., Thannickal, V.J., & Fanburg, B.L.(1994). Glutathione deficiency in human disease.Journal of Nutritional Biochemistry, 5, 218-226.http://www.sciencedirect.com/science/article/pii/0955286394900396
  10. Pace, G.W., & Leaf C.D.(1995). The role of oxidative stress in HIV disease.Free Radical Biology and Medicine, 19, 523-528.http://doi.org/10.1016/0891-5849(95)00053-A
  11. Favier, A., Sappey, C., Leclerc, P., & et al.(1994). Antioxidant status and lipid peroxidation in patients infected with HIV.Chemical Biology Interactions, 91(2-3),165-180.http://doi.org/10.1016/0009-2797(94)90092-X
  12. Nakamura, H., Masutani, H., & Yodoi J.(2002). Redox imbalance and its control in HIV infection.Antioxidants and Redox Signaling, 4(3),455-464.http://doi.org/10.1089/152308602320263580

13.Roberts R.L., Aroda V.R., Ank B.J.(1995). N-acetylcysteine enhances antibody-dependent cellular toxicity in neutrophils and mononuclear cells from healthy adults and human immunodeficiency virus-infected patients.Journal of Infectious Diseases,172(6),1492-1502.http://doi.org/10.1093/infdis/172.6.1492

14.Hu H.L., Forsey R.J., Blades T.J., & et al.(2000). Antioxidants may contribute in the fight against ageing: An in vitro model.Mechanisms of Ageing and Development,121(1-3),217-230.http://doi.org/10.1016/S0047-6374(00)00155-X