Methylation Support®

Methylation Support® by Amy Myers MD – Methylation Support with Activated B Vitamins

Methylation Support® capsules by Amy Myers MD combine four B vitamins with trimethylglycine to support normal methylation. This targeted formula supplies folate as calcium L-5-methyltetrahydrofolate, vitamin B12 as methylcobalamin, and phosphate forms of vitamins B2 and B6.

Unlike a broad multivitamin, this blend concentrates on nutrients involved in transferring small chemical units called methyl groups. Its 60-capsule bottle provides 30 two-capsule servings. The substantial folate amount makes individual nutrient needs and existing supplement use important considerations.

Key Methylation Support® Benefits

• Supports normal homocysteine metabolism through complementary folate, vitamin B12, vitamin B6, and betaine pathways that help the body process this amino acid.
• Provides riboflavin to support cellular energy production and the enzyme systems involved in using nutrients from food.
• Supplies folate for normal DNA synthesis and cell division, alongside vitamin B12 for coordinated one-carbon metabolism.

How Methylation Support® Works

Methylation moves methyl groups between molecules so cells can carry out everyday maintenance. Folate and vitamin B12 work together to recycle homocysteine into methionine, an amino acid used to make the body's principal methyl donor. TMG contributes methyl groups through a separate route. Vitamin B6 supports a different pathway that converts homocysteine toward cysteine. These are complementary nutritional roles, not a reason to assume that everyone needs the same supplement amounts.

Key Functional Ingredients Include:

• Vitamin B2: Riboflavin supplies the building blocks for enzyme helpers that move electrons during energy production. These helpers allow cells to use carbohydrates, fats, and proteins, linking this nutrient to everyday energy metabolism.
• Vitamin B6: Pyridoxal-5-phosphate helps enzymes process amino acids. It supports the pathway that converts homocysteine into cysteine, giving this formula a role beyond recycling homocysteine back into methionine.
• Folate: This formula uses L-5-methyltetrahydrofolate, also called methylfolate. Folate carries one-carbon units needed for normal DNA production and works with vitamin B12 to supply methyl groups during homocysteine recycling.
• Vitamin B12: Supplied as methylcobalamin, this nutrient helps methionine synthase use a methyl group from folate. That step connects folate metabolism with methionine production and the body's ongoing supply of methyl groups.
• Trimethylglycine (TMG): Also known as betaine, TMG donates a methyl group through an enzyme pathway in the liver and kidneys. It complements the folate-dependent route for converting homocysteine into methionine.

Methylation Support® Is Formulated For

• Adults seeking targeted B-vitamin and methyl-donor support.
• Adults reviewing methylfolate-containing supplements with their healthcare practitioner.

Supplements support your health but do not replace a balanced diet. Always check with your healthcare practitioner if you have doubts about a new supplement. Or you may book a FREE product consultation with Holistic Health Partners, led by Carolyn Mulally BS, RN, HN-BC. You may also wish to explore our other Methylation Support Supplements, Cardiovascular Supplements, and Amy Myers MD collections.

Recommendation: Take 2 capsules once daily, or as recommended by your healthcare practitioner.

Serving Size: 2 Capsules
Servings Per Container: 30

Other Ingredients: Hypromellose (vegetable capsule), L-leucine.

Does Not Contain: Gluten, wheat, dairy, soy, GMOs, or yeast.

Additional precautions: Consult your physician before use. Review combined vitamin B6 and folate intake before adding this formula to a multivitamin. Excessive vitamin B6 can cause nerve symptoms. High folate intake can obscure vitamin B12 deficiency. Discuss use with your clinician if you take methotrexate, antiseizure medicines, or sulfasalazine, or if you are pregnant or breastfeeding. Stop use and seek advice if tingling, numbness, or persistent digestive discomfort occurs.

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.