SAMe - 60 CT by Ortho Molecular Products – Methylation Support Capsules
SAMe capsules by Ortho Molecular Products combine S-adenosyl-L-methionine with Quatrefolic folate in a vegetable-capsule formula. This 60-capsule product pairs a naturally occurring methyl donor with an active folate form for focused methylation support, rather than providing a broad multivitamin blend.
The two ingredients participate in connected nutrient pathways. SAMe supplies methyl groups, while folate helps recycle homocysteine back into methionine, the amino acid your body uses to make SAMe. Understanding that partnership helps distinguish this formula from a standalone folate supplement.
Key SAMe - 60 CT Benefits
- Provides a methyl donor used in normal cellular reactions involving proteins, genetic material, and membrane lipids throughout the body.
- Supports normal homocysteine metabolism through active folate, which participates in recycling homocysteine into the amino acid methionine.
- Combines SAMe with the biologically active folate form used in the methionine cycle, bringing two related nutrients into one focused formula.
How SAMe - 60 CT Works
Cellular methylation is the transfer of a small chemical group from one molecule to another. These transfers help cells process important molecules and regulate normal cellular activity. S-adenosyl-L-methionine, commonly called SAMe, carries the methyl groups used in many of these reactions.
Active folate contributes at a different point in the same cycle: it supplies a methyl group needed to turn homocysteine into methionine. This recycling step also depends on vitamin B12; the formula does not supply B12 or replace a complete nutritional assessment.
Key Functional Ingredients Include:
- SAMe: Acts as a methyl donor for normal reactions involving DNA, proteins, and membrane lipids. Methyl groups are small building blocks that help cells modify these molecules for everyday functions. The body makes SAMe from methionine, connecting its role to the amino acid recycling pathway supported by folate.
- Folate: Supports homocysteine metabolism by supplying a methyl group for conversion of homocysteine to methionine. The Quatrefolic form provides 5-MTHF, the active folate used in this step. Its role complements SAMe's methyl-donor function without making the two ingredients interchangeable.
SAMe - 60 CT Is Formulated For
- Adults considering a targeted SAMe-and-folate formula as part of a practitioner-guided supplement plan.
- People who want vegetable capsules with clearly identified active ingredients rather than a multi-ingredient botanical blend.
Supplements support your health but do not replace a balanced diet. Always check with your healthcare practitioner if you have doubts about a new supplement. Or you may book a FREE product consultation with Holistic Health Partners, led by Carolyn Mulally BS, RN, HN-BC. You may also wish to explore our other Methylation Support Supplements and Ortho Molecular Products Supplements and Vitamins collections.
Recommendation: Suggested Use: 1-2 capsules two times per day or as recommended by your health care professional.
Serving Size: 2 Capsules
Servings Per Container: 30
Folate (from 400 mcg as Quatrefolic® (6S)-5-Methyltetrahydrofolic acid glucosamine salt) ... 680 mcg DFE
SAMe (as S-Adenosyl-L-methionine disulfate p-toluensulfonate) ... 400 mg*
* Daily Value not established.
Quatrefolic is a registered trademark of Gnosis S.p.A. Patents Pending.
Other Ingredients: natural Vegetable Capsules, Microcrystalline Cellulose, Silicon Dioxide, Magnesium Stearate
Does Not Contain: Formulated To Be Free Of Allergens Derived From: Gluten, corn, yeast, artificial colors and flavors.
Storage: For best results, keep the desiccant in the bottle until all contents are consumed.
Keep container tightly closed. Refrigerate after opening.
Do not consume this product if you are pregnant or nursing. Consult your physician for further information.
Warning: This product should not be taken with any anti-depressant drugs (MAO Inhibitors, bicyclic, tricyclic, Fluoxetine, etc.) unless under close supervision of your health care professional.
As with all dietary supplements, some individuals may not tolerate or may be allergic to the ingredients used. Please read the ingredient panel carefully prior to ingestion. Cease taking this product and consult your physician if you have negative reactions upon ingestion.
Caution: This product contains a desiccant. For best results, keep the desiccant in the bottle until all contents are consumed. Do not eat desiccant.
This product was sealed for your protection. Do not use if outer logoed neck seal or inner-seal is missing or damaged.
Do not accept if label shows signs of tampering
Keep out of reach of children.
Additional SAMe precautions: SAMe can cause nausea or digestive upset. It may worsen mania in people with bipolar disorder and may decrease levodopa's effects. It can interact with serotonin-increasing medicines and supplements, including L-tryptophan and St. John's wort. People with weakened immune systems should discuss the theoretical concern about Pneumocystis infection with their healthcare professional before use. Long-term safety information is limited.
Frequently Asked Questions About SAMe - 60 CT
What are the benefits of SAMe - 60 CT?
SAMe - 60 CT provides SAMe, a methyl donor used in normal cellular methylation, together with active folate that participates in homocysteine recycling. The two-capsule serving supplies 400 mg SAMe and 680 mcg DFE folate from 400 mcg Quatrefolic. Their complementary roles make this a focused nutrient combination rather than a general multivitamin. SAMe participates directly in methyl transfers, while folate supports the pathway that regenerates methionine. These nutritional roles do not mean the supplement replaces medical care or supplies every nutrient involved in methylation.
Who should take SAMe - 60 CT?
This formula is an option for adults considering SAMe plus active folate with guidance from a healthcare professional. Review your current medicines and supplements first, especially antidepressants, levodopa, or products that increase serotonin. The label says not to consume it during pregnancy or nursing and to keep it out of reach of children. People with bipolar disorder or weakened immune systems need specific professional advice before use. Follow the labeled directions rather than assuming the two-capsule facts-panel serving is the entire daily recommendation.
Are there any side effects of taking SAMe - 60 CT?
SAMe can cause nausea or digestive upset and may worsen mania in bipolar disorder. It can reduce levodopa's effects and interact with serotonin-increasing products, including L-tryptophan and St. John's wort. The label prohibits use during pregnancy or nursing and requires close professional supervision with antidepressants. Stop and consult your physician for negative reactions; check ingredients for allergies. Keep the desiccant in the bottle but never eat it. Reject damaged seals or tampered labels, refrigerate after opening, and keep away from children. With weakened immunity, discuss the theoretical Pneumocystis infection concern before use. Long-term safety information is limited.
How does SAMe - 60 CT support overall health?
SAMe and folate participate in the connected pathways that transfer methyl groups and recycle methionine. These are normal cellular processes involving genetic material, proteins, and membrane lipids, not a promise of a noticeable effect after each dose. Folate contributes to the conversion of homocysteine into methionine, and the body uses methionine to make SAMe. Vitamin B12 is also needed in this recycling pathway but is not included here. A practitioner can help assess this targeted formula alongside your dietary intake and other supplements.
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
1 Review Hide Reviews Show Reviews
-
Review
I have been taking SAMe for years. The quality of product from Covenant Health is stellar and service is prompt and reliable.
