{"num_reviews":2,"add_this":[{"service":"facebook","annotation":""},{"service":"twitter","annotation":""},{"service":"linkedin","annotation":""}],"gtin":null,"brand":{"name":"Microbiome Labs","url":"https://covenanthealthproducts.com/brand/microbiome-labs"},"id":26034,"can_purchase":true,"meta_description":"MegaSporeBiotic supports gut health, microbial balance, and digestion with spore-based probiotics designed for resilience and optimal intestinal support.","category":["Brands/Microbiome Labs Supplements","GLP-1 Support Supplements","GLP-1 Support Supplements/GLP-1 Gut Health"],"AddThisServiceButtonMeta":"","main_image":{"data":"https://cdn11.bigcommerce.com/s-35tuw7jhw2/images/stencil/{:size}/products/26034/38611/megaspore-biotic-60c-microbiome-labs__75500.1760540447.jpg?c=1","alt":"MegasporeBiotic - Microbiome Labs"},"add_to_wishlist_url":"https://covenanthealthproducts.com/wishlist.php?action=add&product_id=26034","shipping":{"calculated":true},"custom_fields":[{"id":"110435","name":"Questions","value":"<a href='/complimentary-product-consultation/'><img src=https://cdn11.bigcommerce.com/s-35tuw7jhw2/product_images/uploaded_images/need_someone_to_talk_to_250px.png\"></a><div><a href=\"/need-product-help\">Talk to an Expert</a></div>"},{"id":"124060","name":"Blog Post","value":"<a href=\"/our-blog/megasporebiotic-by-microbiome-labs-spore-based-probiotic\"><img src=\"https://cdn11.bigcommerce.com/s-35tuw7jhw2/product_images/uploaded_images/blog_post_result_250.webp\"> </a> <a href=\"/blog\">View Blog Post</a>"},{"id":"172288","name":"klaviyo_tags","value":"type:probiotic | goal:gut-health | goal:microbiome-support | goal:immune-support | goal:digestive-support | goal:immune-defense | goal:cellular-health | goal:antioxidant-support | protocol:gut-repair-stack | protocol:microbiome-stack | form:capsule"}],"sku":"MIC630-10010523237","backorder_availability_prompt":"","url":"https://covenanthealthproducts.com/megasporebiotic-180.html","description":"<!-- Store: CHP | Product: MegaSporeBiotic™ | Brand: Microbiome Labs -->\n<h2>MegaSporeBiotic by Microbiome Labs &ndash; Spore-Based Probiotic for Gut Barrier and Microbial Diversity Support</h2>\n<p><strong>MegaSporeBiotic</strong> by <strong>Microbiome Labs</strong> is a 100% <strong>spore-based probiotic</strong> designed to support healthy gut barrier function and microbial diversity. This broad-spectrum <strong>5-strain Bacillus probiotic</strong> is engineered to survive digestion, reach the large intestine intact, and help recondition the gut microbiome. Shelf-stable with no refrigeration required, MegaSporeBiotic has become a trusted daily probiotic among wellness practitioners and their clients.</p>\n<h3>Key MegaSporeBiotic Benefits</h3>\n<ul>\n<li>Supports a healthy <strong>gut barrier</strong> and intestinal lining integrity</li>\n<li>Promotes <strong>microbial diversity</strong> and commensal bacteria balance in the gut</li>\n<li>Helps maintain healthy immune function</li>\n<li>Assists the body in producing short-chain fatty acids (SCFAs) in the colon</li>\n<li>Shelf-stable with a 5-year shelf life and no refrigeration required</li>\n</ul>\n<h3>How MegaSporeBiotic Works</h3>\n<p>MegaSporeBiotic uses the bi-phasic life cycle of <strong>Bacillus spores</strong>, which remain dormant in harsh environments and activate only once they reach the favorable conditions of the large intestine. Rather than attempting to reseed the gut with strains that often cannot survive stomach acid, this formula aims to <strong>recondition the gut microbiome</strong> by encouraging the growth of health-promoting, commensal bacteria already native to the digestive tract.</p>\n<h4>Key Functional Ingredients Include:</h4>\n<ul>\n<li><strong><a title=\"Treatment with a spore-based probiotic containing five strains of Bacillus induced changes in the metabolic activity and community composition of the gut microbiota in a SHIME&reg; model of the human gastrointestinal system\" href=\"https://pubmed.ncbi.nlm.nih.gov/34600678/\" target=\"_blank\" rel=\"noopener\">Bacillus indicus</a> HU36&trade;</strong>: Produces carotenoid antioxidants including lycopene, astaxanthin, beta-carotene, and lutein at the site of absorption in the gut</li>\n<li><strong><a title=\"The probiotic Bacillus subtilis BS50 decreases gastrointestinal symptoms in healthy adults: a randomized, double-blind, placebo-controlled trial\" href=\"Treatment%20with a spore-based probiotic containing five strains of Bacillus induced changes in the metabolic activity and community composition of the gut microbiota in a SHIME&reg; model of the human gastrointestinal system\" target=\"_blank\" rel=\"noopener\">Bacillus subtilis</a> HU58&trade;</strong>: Supports healthy gut-associated lymphoid tissue (GALT) development and produces vitamin K2</li>\n<li><strong><a title=\"Testing the Immunomodulatory Effects of Probiotic Bacillus coagulans SNZ 1969&reg; in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Trial\" href=\"https://pubmed.ncbi.nlm.nih.gov/41262831/\" target=\"_blank\" rel=\"noopener\">Bacillus coagulans</a> (SC-208)</strong>: Produces L+ lactic acid and supports immune function</li>\n<li><strong><a title=\"Potential application of the probiotic Bacillus licheniformis as an adjuvant in the treatment of diseases in humans and animals: A systematic review\" href=\"https://pubmed.ncbi.nlm.nih.gov/36225361/\" target=\"_blank\" rel=\"noopener\">Bacillus licheniformis</a> (SL-307)</strong>: Produces proteases that assist protein digestion and helps produce the full spectrum of B vitamins</li>\n<li><strong><a title=\"Current Progress and Future Perspectives on the Use of Bacillus clausii\" href=\"https://pubmed.ncbi.nlm.nih.gov/35744764/\" target=\"_blank\" rel=\"noopener\">Bacillus clausii</a> (SC-109)</strong>: Supports immune balance and helps maintain normal intestinal flora during antibiotic use</li>\n</ul>\n<p>MegaSporeBiotic is free from dairy, gluten, soy, corn, wheat, rice, sugar, salt, GMOs, and artificial colors or flavors, making it suitable for a wide range of dietary preferences.</p>\n<h3>MegaSporeBiotic Is Formulated For</h3>\n<ul>\n<li>Adults looking to support daily <strong>gut health</strong> and digestive balance</li>\n<li>Individuals interested in a <strong>spore-forming probiotic</strong> designed to survive the digestive tract</li>\n<li>Anyone supporting microbial diversity as part of a broader wellness routine</li>\n<li>Those who want a shelf-stable probiotic that does not require refrigeration</li>\n<li>People working with a practitioner on a gut-reconditioning protocol</li>\n</ul>\n<p><strong>Supplements support your health but do not replace a balanced diet.</strong> Always check with your healthcare practitioner if you have doubts about a new supplement. Or you may book a<a title=\"Complimentary Product Consultation\" href=\"https://covenanthealthproducts.com/complimentary-product-consultation/\" target=\"_blank\" rel=\"noopener\"><strong> FREE product consultation </strong></a>with Holistic Health Partners. You may also want to explore our <a href=\"https://covenanthealthproducts.com/clinic-recommended-products/gi-health-supplements/\"><strong>GI Health Supplements</strong></a> collection.</p>\n<p><strong>Recommendation:</strong> Ages 5+: Start with 1/2 capsule or 1 full capsule with a meal and slowly increase using the following protocol &mdash; Week 1: 1 capsule every other day. Week 2: 1 capsule daily. Week 3+: 2 capsules daily. Children under 5 years of age, please consult with your healthcare practitioner.</p>\n<p><strong>Serving Size:</strong> 2 Capsules<br /><strong>Servings Per Container:</strong> 30 (60-count) or 90 (180-count)</p>\n<div><strong>Amount Per Serving:</strong><br />Proprietary Probiotic Blend (4 Billion CFU) ... 295 mg<br />Bacillus indicus HU36&trade; ... &dagger;<br />Bacillus subtilis HU58&trade; ... &dagger;<br />Bacillus coagulans (SC-208) ... &dagger;<br />Bacillus licheniformis (SL-307) ... &dagger;<br />Bacillus clausii (SC-109) ... &dagger;<br />\n<p>&dagger; Daily values not established.</p>\n</div>\n<p><strong>Other Ingredients:</strong> Cellulose, vegetable capsule (cellulose and water).</p>\n<p><strong>Does not contain:</strong> Gluten, GMOs, dairy, wheat, corn, rice, salt, sugar, soy, artificial colors, or artificial flavors.</p>\n<p><strong>Warnings/Cautions:</strong> If you are pregnant, nursing, have a medical condition, or are taking medications, consult your physician before using this product. Possible temporary side effects may include abdominal cramping, loose stools, and changes in bowel movements; these typically resolve within 2-3 days.</p>\n<p><em>These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.</em></p>\n<p><a title=\"Product Info Sheet\" href=\"https://brands.microbiomelabs.com/document/59/show/eyJpZCI6MTY2NDEsInRpbWVzdGFtcCI6IjE3MTE0NjE1MDkifQ:novozymes:3ucfJMIw5fIeUJKLyi_U7HEn6tjETCQ-ngTRnCYWvmU\">Click here to view Product Info Sheet</a></p>","show_backorder_message":false,"tags":[],"warranty":"","price":{"without_tax":{"formatted":"$66.25","value":66.25,"currency":"USD"},"tax_label":"Tax"},"default_shipping_expectation_prompt":"","detail_messages":"","availability":"Usually Ships in 48 to 72 Hours","page_title":"MegasporeBiotic | Microbiome Labs","cart_url":"https://covenanthealthproducts.com/cart.php","show_backorder_availability_prompt":false,"max_purchase_quantity":0,"show_quantity_on_hand":true,"show_default_shipping_expectation_prompt":false,"show_quantity_on_backorder":false,"mpn":null,"upc":null,"options":[{"id":47040,"type":"Configurable_PickList_Set","display_name":"Size","required":true,"state":"variant_option","partial":"set-rectangle","condition":true,"values":[{"id":160434,"label":"60 CT","selected":true,"data":"60 CT"},{"id":160435,"label":"180 CT","selected":false,"data":"180 CT"}]},{"id":44760,"type":"Configurable_PickList_Set","display_name":"Recurring Order","required":true,"state":"modifier","partial":"set-select","condition":true,"values":[{"id":48845,"label":"One Time Purchase","selected":true,"data":"One Time Purchase"},{"id":48846,"label":"Every 20 Days","selected":false,"data":"Every 20 Days"},{"id":48847,"label":"Every 30 Days","selected":false,"data":"Every 30 Days"},{"id":48848,"label":"Every 40 Days","selected":false,"data":"Every 40 Days"},{"id":159647,"label":"Every 45 Days","selected":false,"data":"Every 45 Days"},{"id":48849,"label":"Every 60 Days","selected":false,"data":"Every 60 Days"},{"id":48850,"label":"Every 90 Days","selected":false,"data":"Every 90 Days"},{"id":48851,"label":"Every 120 Days","selected":false,"data":"Every 120 Days"},{"id":48852,"label":"Every 180 Days","selected":false,"data":"Every 180 Days"}]}],"related_products":[{"id":29167,"sku":"MIC630-6935256","name":"MegaSporeBiotic Gummies 60ct","url":"https://covenanthealthproducts.com/megasporebiotic-gummies-60ct-by-microbiome-labs/","availability":"Usually Ships in 48 to 72 Hours","rating":0,"brand":{"name":"Microbiome Labs"},"category":["Brands/Microbiome Labs Supplements"],"summary":"MegaSporeBiotic Gummies by Microbiome Labs\nIntroduction:\nMegaSporeBiotic Gummies offer the trusted power of spore-based probiotics in a great-tasting, shelf-stable gummy. With 4 billion CFU per...","image":{"data":"https://cdn11.bigcommerce.com/s-35tuw7jhw2/images/stencil/{:size}/products/29167/44790/MegaSporeProbioticGummies-60g-MicrobiomeLabs__26065.1756202280.jpg?c=1","alt":"MegaSporeBiotic Gummies 60ct by Microbiome Labs"},"images":[{"data":"https://cdn11.bigcommerce.com/s-35tuw7jhw2/images/stencil/{:size}/products/29167/44790/MegaSporeProbioticGummies-60g-MicrobiomeLabs__26065.1756202280.jpg?c=1","alt":"MegaSporeBiotic Gummies 60ct by Microbiome Labs"}],"date_added":"Aug 26, 2025","pre_order":false,"show_cart_action":true,"has_options":true,"stock_level":null,"low_stock_level":null,"qty_in_cart":0,"custom_fields":[{"id":160955,"name":"Questions","value":"<a href='/complimentary-product-consultation/'><img src=https://cdn11.bigcommerce.com/s-35tuw7jhw2/product_images/uploaded_images/need_someone_to_talk_to_250px.png\"></a><div><a href=\"/need-product-help\">Talk to an Expert</a></div>"},{"id":174787,"name":"klaviyo_tags","value":"type:probiotic | goal:gut-health | goal:microbiome-support | goal:immune-support | goal:digestive-support | goal:immune-defense | goal:cellular-health | goal:antioxidant-support | protocol:gut-repair-stack | protocol:microbiome-stack | form:gummy"}],"num_reviews":0,"weight":{"formatted":"0.25 Ounces","value":0.25},"demo":false,"add_to_wishlist_url":"https://covenanthealthproducts.com/wishlist.php?action=add&product_id=29167","price":{"without_tax":{"currency":"USD","formatted":"$57.96","value":57.96},"tax_label":"Tax"}},{"id":29168,"sku":"MIC630-6935309","name":"MegaSporeBiotic Gummies For Kids 30ct","url":"https://covenanthealthproducts.com/megasporebiotic-gummies-for-kids-30ct-by-microbiome-labs/","availability":"Usually Ships in 48 to 72 Hours","rating":0,"brand":{"name":"Microbiome Labs"},"category":["Brands/Microbiome Labs Supplements"],"summary":"MegaSporeBiotic Gummies for Kids by Microbiome Labs\nIntroduction:\nMegaSporeBiotic Gummies for Kids deliver the same trusted spore-based probiotic strains found in the original formula, now in a...","image":{"data":"https://cdn11.bigcommerce.com/s-35tuw7jhw2/images/stencil/{:size}/products/29168/44791/MegaSporeBioticGummiesForKids-30g-MicrobiomeLabs__89012.1756202574.jpg?c=1","alt":"MegaSporeBiotic Gummies for Kids 30ct by Microbiome Labs"},"images":[{"data":"https://cdn11.bigcommerce.com/s-35tuw7jhw2/images/stencil/{:size}/products/29168/44791/MegaSporeBioticGummiesForKids-30g-MicrobiomeLabs__89012.1756202574.jpg?c=1","alt":"MegaSporeBiotic Gummies for Kids 30ct by Microbiome Labs"}],"date_added":"Aug 26, 2025","pre_order":false,"show_cart_action":true,"has_options":true,"stock_level":null,"low_stock_level":null,"qty_in_cart":0,"custom_fields":[{"id":160956,"name":"Questions","value":"<a href='/complimentary-product-consultation/'><img src=https://cdn11.bigcommerce.com/s-35tuw7jhw2/product_images/uploaded_images/need_someone_to_talk_to_250px.png\"></a><div><a href=\"/need-product-help\">Talk to an Expert</a></div>"},{"id":174788,"name":"klaviyo_tags","value":"type:probiotic | goal:gut-health | goal:microbiome-support | goal:immune-support | goal:digestive-support | goal:immune-defense | goal:antioxidant-support | protocol:gut-repair-stack | protocol:microbiome-stack | form:gummy | audience:children"}],"num_reviews":0,"weight":{"formatted":"0.25 Ounces","value":0.25},"demo":false,"add_to_wishlist_url":"https://covenanthealthproducts.com/wishlist.php?action=add&product_id=29168","price":{"without_tax":{"currency":"USD","formatted":"$30.44","value":30.44},"tax_label":"Tax"}}],"shipping_messages":[],"rating":5,"reviews":{"messages":[],"total":2,"show_review_email":true,"end":2,"start":1,"list":[{"name":"Susan","rating":"5","title":"Best Probiotic on the market","text":"My wellness doctor recommended this after I had cancer surgery and it has kept me cancer-free and health for over 15 years - not even a cold! \r\n ","date":"Sep 05, 2025"},{"name":"Susan C","rating":"5","title":"BEST PROBIOTIC","text":"My nutrition doctor recommended this and I have been taking it for over 10 years and I never get sick with a cold or anything else. Can&#039;t live without it!!! \r\n ","date":"Apr 18, 2025"}]},"bulk_discount_rates":[],"meta_keywords":"","show_quantity_input":1,"title":"MegasporeBiotic","gift_wrapping_available":false,"min_purchase_quantity":0,"customizations":[],"images":[{"data":"https://cdn11.bigcommerce.com/s-35tuw7jhw2/images/stencil/{:size}/products/26034/38611/megaspore-biotic-60c-microbiome-labs__75500.1760540447.jpg?c=1","alt":"MegasporeBiotic - Microbiome Labs"},{"data":"https://cdn11.bigcommerce.com/s-35tuw7jhw2/images/stencil/{:size}/products/26034/46188/MegasporeBiotic_-_Microbiome_Labs_Label__87048.1760540448.png?c=1","alt":"MegasporeBiotic - Microbiome Labs Label"}]}

MegasporeBiotic

Microbiome Labs

$66.25
(2 reviews) Write a Review
SKU:
MIC630-10010523237
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MegaSporeBiotic by Microbiome Labs – Spore-Based Probiotic for Gut Barrier and Microbial Diversity Support

MegaSporeBiotic by Microbiome Labs is a 100% spore-based probiotic designed to support healthy gut barrier function and microbial diversity. This broad-spectrum 5-strain Bacillus probiotic is engineered to survive digestion, reach the large intestine intact, and help recondition the gut microbiome. Shelf-stable with no refrigeration required, MegaSporeBiotic has become a trusted daily probiotic among wellness practitioners and their clients.

Key MegaSporeBiotic Benefits

  • Supports a healthy gut barrier and intestinal lining integrity
  • Promotes microbial diversity and commensal bacteria balance in the gut
  • Helps maintain healthy immune function
  • Assists the body in producing short-chain fatty acids (SCFAs) in the colon
  • Shelf-stable with a 5-year shelf life and no refrigeration required

How MegaSporeBiotic Works

MegaSporeBiotic uses the bi-phasic life cycle of Bacillus spores, which remain dormant in harsh environments and activate only once they reach the favorable conditions of the large intestine. Rather than attempting to reseed the gut with strains that often cannot survive stomach acid, this formula aims to recondition the gut microbiome by encouraging the growth of health-promoting, commensal bacteria already native to the digestive tract.

Key Functional Ingredients Include:

  • Bacillus indicus HU36™: Produces carotenoid antioxidants including lycopene, astaxanthin, beta-carotene, and lutein at the site of absorption in the gut
  • Bacillus subtilis HU58™: Supports healthy gut-associated lymphoid tissue (GALT) development and produces vitamin K2
  • Bacillus coagulans (SC-208): Produces L+ lactic acid and supports immune function
  • Bacillus licheniformis (SL-307): Produces proteases that assist protein digestion and helps produce the full spectrum of B vitamins
  • Bacillus clausii (SC-109): Supports immune balance and helps maintain normal intestinal flora during antibiotic use

MegaSporeBiotic is free from dairy, gluten, soy, corn, wheat, rice, sugar, salt, GMOs, and artificial colors or flavors, making it suitable for a wide range of dietary preferences.

MegaSporeBiotic Is Formulated For

  • Adults looking to support daily gut health and digestive balance
  • Individuals interested in a spore-forming probiotic designed to survive the digestive tract
  • Anyone supporting microbial diversity as part of a broader wellness routine
  • Those who want a shelf-stable probiotic that does not require refrigeration
  • People working with a practitioner on a gut-reconditioning protocol

Supplements support your health but do not replace a balanced diet. Always check with your healthcare practitioner if you have doubts about a new supplement. Or you may book a FREE product consultation with Holistic Health Partners. You may also want to explore our GI Health Supplements collection.

Recommendation: Ages 5+: Start with 1/2 capsule or 1 full capsule with a meal and slowly increase using the following protocol — Week 1: 1 capsule every other day. Week 2: 1 capsule daily. Week 3+: 2 capsules daily. Children under 5 years of age, please consult with your healthcare practitioner.

Serving Size: 2 Capsules
Servings Per Container: 30 (60-count) or 90 (180-count)

Amount Per Serving:
Proprietary Probiotic Blend (4 Billion CFU) ... 295 mg
Bacillus indicus HU36™ ... †
Bacillus subtilis HU58™ ... †
Bacillus coagulans (SC-208) ... †
Bacillus licheniformis (SL-307) ... †
Bacillus clausii (SC-109) ... †

† Daily values not established.

Other Ingredients: Cellulose, vegetable capsule (cellulose and water).

Does not contain: Gluten, GMOs, dairy, wheat, corn, rice, salt, sugar, soy, artificial colors, or artificial flavors.

Warnings/Cautions: If you are pregnant, nursing, have a medical condition, or are taking medications, consult your physician before using this product. Possible temporary side effects may include abdominal cramping, loose stools, and changes in bowel movements; these typically resolve within 2-3 days.

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Click here to view Product Info Sheet

2 Reviews Hide Reviews Show Reviews

  • 5
    Best Probiotic on the market

    Posted by Susan on Sep 05, 2025

    My wellness doctor recommended this after I had cancer surgery and it has kept me cancer-free and health for over 15 years - not even a cold!

  • 5
    BEST PROBIOTIC

    Posted by Susan C on Apr 18, 2025

    My nutrition doctor recommended this and I have been taking it for over 10 years and I never get sick with a cold or anything else. Can't live without it!!!