{"num_reviews":0,"url":"https://covenanthealthproducts.com/histamend-dao-60c-by-numedica/","add_this":[{"service":"facebook","annotation":""},{"service":"twitter","annotation":""},{"service":"linkedin","annotation":""}],"gtin":null,"brand":{"name":"NuMedica","url":"https://covenanthealthproducts.com/numedica/"},"id":27876,"can_purchase":true,"meta_description":"HistaMend DAO™ by NuMedica supports histamine metabolism and gastrointestinal symptom relief with DAO enzyme and pine bark extract.","category":["Brands/Numedica Supplements and Vitamins"],"AddThisServiceButtonMeta":"","main_image":{"data":"https://cdn11.bigcommerce.com/s-35tuw7jhw2/images/stencil/{:size}/products/27876/34004/HistaMend-DAO-60vc-NuMedica__76196.1729703162.jpg?c=1","alt":"HistaMend DAO 60c by NuMedica"},"add_to_wishlist_url":"/wishlist.php?action=add&product_id=27876","shipping":{"calculated":true},"custom_fields":[{"id":"142120","name":"Brand","value":"<a href='/brands/numedica/'><img src=https://cdn11.bigcommerce.com/s-35tuw7jhw2/product_images/uploaded_images/brand-logos/numedica_278x90.png\" width=\"278\" height=\"90\"></a>"},{"id":"142121","name":"Questions","value":"<a href='/complimentary-product-consultation/'><img src=https://cdn11.bigcommerce.com/s-35tuw7jhw2/product_images/uploaded_images/need_someone_to_talk_to_250px.png\"></a><div><a href=\"/need-product-help\">Talk to an Expert</a></div>"}],"sku":"NM-NM323","description":"<h2><strong>HistaMend DAO&trade; by NuMedica &ndash; Advanced Diamine Oxidase Support for Histamine Intolerance</strong></h2>\n<p><strong>HistaMend DAO&trade; by NuMedica</strong> is a targeted diamine <strong>oxidase supplement</strong> designed to support <strong>histamine metabolism</strong> in the digestive tract and promote <strong>gastrointestinal symptom</strong> relief. This advanced formula combines <strong>DAO enzyme</strong> activity with <strong>antioxidant-rich pine bark</strong> extract to help degrade dietary histamine and <strong>reduce histamine intolerance symptoms</strong>. Pine bark is a potent free radical scavenger known to inhibit histamine release from mast cells and support intestinal barrier integrity by upregulating tight junction protein expression. Taking HistaMend DAO&trade; prior to consuming high-histamine foods and beverages helps maintain comfort and <strong>digestive balance</strong>.</p>\n<h3><strong>Key HistaMend DAO&trade; Benefits</strong></h3>\n<ul>\n<li>Supports healthy <strong>histamine metabolism</strong> in the gut</li>\n<li>Helps reduce symptoms associated with <strong>histamine intolerance</strong></li>\n<li>Promotes <strong>gastrointestinal comfort</strong> and function</li>\n<li>Includes <strong>pine bark extract</strong> for antioxidants and mast cell support</li>\n<li>Aids in maintaining<strong> intestinal barrier integrity</strong> and tight junction health</li>\n</ul>\n<h3 id=\"h_6393081071759866725588\"><strong>How HistaMend DAO&trade; Works</strong></h3>\n<p>HistaMend DAO&trade; provides natural diamine oxidase (DAO) enzyme derived from porcine kidney extract, which helps break down excess histamine from food before it can cause discomfort.</p>\n<ul>\n<li><a title=\"Diamine oxidase supplementation improves symptoms in patients with histamine intolerance\" href=\"#h_6393081071759866725588\" target=\"_blank\" rel=\"noopener\"><strong>DAO Enzyme:</strong></a> Enhances the breakdown of dietary histamine, reducing intolerance symptoms.</li>\n<li><a title=\"Editorial: Pine bark extract: nutrition and metabolism\" href=\"https://pmc.ncbi.nlm.nih.gov/articles/PMC11428702/\" target=\"_blank\" rel=\"noopener\"><strong>Pine Bark Extract (95% proanthocyanidins):</strong></a> Acts as a powerful antioxidant and supports healthy mast cell response.</li>\n<li><a title=\"Therapeutic potentials of catalase: Mechanisms, applications, and future perspectives\" href=\"https://pmc.ncbi.nlm.nih.gov/articles/PMC10915913/\" target=\"_blank\" rel=\"noopener\"><strong>Catalase and Vitamin C:</strong></a> Work synergistically to protect against oxidative stress and enhance enzyme activity.</li>\n</ul>\n<p>This formula is well-tolerated and designed for <strong>safe</strong>, everyday use with <strong>minimal side effects</strong> when taken as directed.</p>\n<h3><strong>Who Should Use HistaMend DAO&trade;</strong></h3>\n<p>HistaMend DAO&trade; is ideal for individuals seeking <strong>safe</strong> and <strong>effective</strong> gastrointestinal symptom relief related to histamine intolerance. It&rsquo;s especially suited for those who experience discomfort after consuming aged, fermented, or histamine-rich foods and who wish to support <strong>joint</strong>, <strong>bone</strong>, and <strong>skin health</strong> through balanced histamine metabolism.</p>\n<p><strong>Supplements support your health but do not replace a balanced diet</strong>. Always check with your healthcare practitioner if you have doubts about a new supplement. Or you may book a <a title=\"Complimentary Product Consultation\" href=\"https://covenanthealthproducts.com/complimentary-product-consultation/\" target=\"_blank\" rel=\"noopener\"><strong>FREE product consultation</strong></a> with Holistic Health Partners<em>.</em> You may also want to explore our other <a title=\"GI Health Supplements\" href=\"#h_6393081071759866725588\" target=\"_blank\" rel=\"noopener\"><strong>GI Health</strong></a> and <a title=\"Anti-Oxidants Supplements\" href=\"#h_6393081071759866725588\" target=\"_blank\" rel=\"noopener\"><strong>Anti-Oxidants</strong></a> products.</p>\n<div><strong>Recommendation:</strong><br />NuMedica suggests taking <strong>one capsule 1&ndash;2 times per day before a meal</strong> or as directed by your healthcare practitioner.</div>\n<div>&nbsp;</div>\n<div><strong>Serving Size:</strong> 1 Capsule<br /><strong>Servings Per Container:</strong> 60</div>\n<div>&nbsp;</div>\n<div><strong>Amount Per Serving:</strong></div>\n<div>Vitamin C (as ascorbyl palmitate) 10 mg</div>\n<div>Maritime Pine (Pinus pinaster) (bark) extract (95% proanthocyanidins) 100 mg</div>\n<div>Catalase (125 BU) 5 mg</div>\n<div>DAO (diamine oxidase)&dagger; (from porcine kidney extract) (24,000 HDU) 4.20 mg</div>\n<p><strong>Other Ingredients:</strong><br />Digestive-resistant vegetable capsule (hydroxypropyl methylcellulose, gellan gum), microcrystalline cellulose, magnesium stearate, silicon dioxide.</p>\n<p><strong>Does Not Contain:</strong><br /><strong>Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy.</strong></p>\n<p><strong>Caution:</strong><br />If you are pregnant, nursing, or taking any medications, consult your healthcare practitioner before use. Keep out of reach of children.</p>\n<p><strong>Storage:</strong><br />Keep tightly closed in a cool, dry place.</p>\n<p><em>These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.</em></p>\n<p><strong>Trademark:</strong> &dagger;DAOgest is a registered trademark of BIOIBERICA, S.A.U.</p>","tags":[],"warranty":"","price":{"without_tax":{"formatted":"$57.95","value":57.95,"currency":"USD"},"tax_label":"Tax"},"detail_messages":"","availability":"Allow 5 to 7 business days for delivery","page_title":"HistaMend DAO 60c | NuMedica","cart_url":"https://covenanthealthproducts.com/cart.php","max_purchase_quantity":0,"mpn":"NM323","upc":null,"options":[{"id":46445,"type":"Configurable_PickList_Set","display_name":"Recurring Order","required":true,"state":"modifier","partial":"set-select","condition":true,"values":[{"id":48845,"label":"One Time Purchase","selected":true,"data":"One Time Purchase"},{"id":48846,"label":"Every 20 Days","selected":false,"data":"Every 20 Days"},{"id":48847,"label":"Every 30 Days","selected":false,"data":"Every 30 Days"},{"id":48848,"label":"Every 40 Days","selected":false,"data":"Every 40 Days"},{"id":159647,"label":"Every 45 Days","selected":false,"data":"Every 45 Days"},{"id":48849,"label":"Every 60 Days","selected":false,"data":"Every 60 Days"},{"id":48850,"label":"Every 90 Days","selected":false,"data":"Every 90 Days"},{"id":48851,"label":"Every 120 Days","selected":false,"data":"Every 120 Days"},{"id":48852,"label":"Every 180 Days","selected":false,"data":"Every 180 Days"}]}],"related_products":[{"id":28679,"sku":"PUR-DAE6","name":"DAO Enzyme 60c","url":"https://covenanthealthproducts.com/dao-enzyme-60c/","availability":"Ships Same Business Day","rating":0,"brand":{"name":"Pure Encapsulations"},"category":["Brands/Pure Encapsulations Supplements and Vitamins","Clinic Recommended Products/Cardiovascular Supplements"],"summary":"DAO Enzyme by Pure Encapsulations – Support for Histamine Sensitivity and GI Comfort\nDAO Enzyme by Pure Encapsulations is a targeted supplement designed to help the body metabolize dietary histamine,...","image":{"data":"https://cdn11.bigcommerce.com/s-35tuw7jhw2/images/stencil/{:size}/products/28679/42252/DAO_Enzyme_by_Pure_Encapsulations__47740.1750099573.png?c=1","alt":"DAO Enzyme by Pure Encapsulations"},"images":[{"data":"https://cdn11.bigcommerce.com/s-35tuw7jhw2/images/stencil/{:size}/products/28679/42252/DAO_Enzyme_by_Pure_Encapsulations__47740.1750099573.png?c=1","alt":"DAO Enzyme by Pure Encapsulations"},{"data":"https://cdn11.bigcommerce.com/s-35tuw7jhw2/images/stencil/{:size}/products/28679/42253/DAO_Enzyme_Label_by_Pure_Encapsulations__95068.1750099573.png?c=1","alt":"DAO Enzyme Label by Pure Encapsulations"}],"date_added":"Jun 16, 2025","pre_order":false,"show_cart_action":true,"has_options":false,"stock_level":null,"low_stock_level":null,"qty_in_cart":0,"custom_fields":[{"id":160164,"name":"Brand","value":"<a href='/brands/pure-encapsulations/'><img 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for Health is a specialized DAO supplement designed to help break down food-derived histamines...","image":{"data":"https://cdn11.bigcommerce.com/s-35tuw7jhw2/images/stencil/{:size}/products/27364/44469/hgd060_histagest-dao__56248.1754160804.jpg?c=1","alt":"HistaGest DAO 60t by Designs for Health"},"images":[{"data":"https://cdn11.bigcommerce.com/s-35tuw7jhw2/images/stencil/{:size}/products/27364/44469/hgd060_histagest-dao__56248.1754160804.jpg?c=1","alt":"HistaGest DAO 60t by Designs for Health"},{"data":"https://cdn11.bigcommerce.com/s-35tuw7jhw2/images/stencil/{:size}/products/27364/43188/HistaGest_DAO_60t_Label_by_Designs_for_Health__60205.1751393053.png?c=1","alt":"HistaGest DAO 60t Label by Designs for Health"}],"date_added":"Feb 09, 2023","pre_order":false,"show_cart_action":true,"has_options":true,"stock_level":null,"low_stock_level":null,"qty_in_cart":0,"custom_fields":[{"id":151214,"name":"Brand","value":"<a href='/brands/designs-for-health/'><img 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href=\"/need-product-help\">Talk to an Expert</a></div>"},{"id":158523,"name":"Ship time","value":"Ships Same Business Day"}],"num_reviews":0,"weight":{"formatted":"0.00 Ounces","value":0},"demo":false,"show_quantity_on_backorder":true,"show_quantity_on_hand":true,"show_backorder_message":true,"show_backorder_availability_prompt":true,"backorder_availability_prompt":"More available for backorder","price":{"without_tax":{"currency":"USD","formatted":"$38.00","value":38},"tax_label":"Tax"},"add_to_wishlist_url":"/wishlist.php?action=add&product_id=15983"},{"id":22855,"sku":"PUR-P17631","name":"MenoVive 60c","url":"https://covenanthealthproducts.com/menovive-60-capsules-by-pure-encapsulations","availability":"Ships Same Business Day","rating":0,"brand":{"name":"Pure Encapsulations"},"category":["Brands/Pure Encapsulations Supplements and Vitamins"],"summary":"\nMenoVive 60c by Pure Encapsulations\nMenoVive by Pure Encapsulations is a unique dietary supplement that has been formulated to 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HistaMend DAO 60c by NuMedica

HistaMend DAO 60c

NuMedica

$57.95
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SKU:
NM-NM323
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Product Help Desk - Ask about products or ingredients or health conditions

HistaMend DAO™ by NuMedica – Advanced Diamine Oxidase Support for Histamine Intolerance

HistaMend DAO™ by NuMedica is a targeted diamine oxidase supplement designed to support histamine metabolism in the digestive tract and promote gastrointestinal symptom relief. This advanced formula combines DAO enzyme activity with antioxidant-rich pine bark extract to help degrade dietary histamine and reduce histamine intolerance symptoms. Pine bark is a potent free radical scavenger known to inhibit histamine release from mast cells and support intestinal barrier integrity by upregulating tight junction protein expression. Taking HistaMend DAO™ prior to consuming high-histamine foods and beverages helps maintain comfort and digestive balance.

Key HistaMend DAO™ Benefits

  • Supports healthy histamine metabolism in the gut
  • Helps reduce symptoms associated with histamine intolerance
  • Promotes gastrointestinal comfort and function
  • Includes pine bark extract for antioxidants and mast cell support
  • Aids in maintaining intestinal barrier integrity and tight junction health

How HistaMend DAO™ Works

HistaMend DAO™ provides natural diamine oxidase (DAO) enzyme derived from porcine kidney extract, which helps break down excess histamine from food before it can cause discomfort.

This formula is well-tolerated and designed for safe, everyday use with minimal side effects when taken as directed.

Who Should Use HistaMend DAO™

HistaMend DAO™ is ideal for individuals seeking safe and effective gastrointestinal symptom relief related to histamine intolerance. It’s especially suited for those who experience discomfort after consuming aged, fermented, or histamine-rich foods and who wish to support joint, bone, and skin health through balanced histamine metabolism.

Supplements support your health but do not replace a balanced diet. Always check with your healthcare practitioner if you have doubts about a new supplement. Or you may book a FREE product consultation with Holistic Health Partners. You may also want to explore our other GI Health and Anti-Oxidants products.

Recommendation:
NuMedica suggests taking one capsule 1–2 times per day before a meal or as directed by your healthcare practitioner.
 
Serving Size: 1 Capsule
Servings Per Container: 60
 
Amount Per Serving:
Vitamin C (as ascorbyl palmitate) 10 mg
Maritime Pine (Pinus pinaster) (bark) extract (95% proanthocyanidins) 100 mg
Catalase (125 BU) 5 mg
DAO (diamine oxidase)† (from porcine kidney extract) (24,000 HDU) 4.20 mg

Other Ingredients:
Digestive-resistant vegetable capsule (hydroxypropyl methylcellulose, gellan gum), microcrystalline cellulose, magnesium stearate, silicon dioxide.

Does Not Contain:
Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy.

Caution:
If you are pregnant, nursing, or taking any medications, consult your healthcare practitioner before use. Keep out of reach of children.

Storage:
Keep tightly closed in a cool, dry place.

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Trademark: †DAOgest is a registered trademark of BIOIBERICA, S.A.U.

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