{"num_reviews":0,"url":"https://covenanthealthproducts.com/curcumin-phytosome-by-thorne","add_this":[{"service":"facebook","annotation":""},{"service":"twitter","annotation":""},{"service":"linkedin","annotation":""}],"gtin":null,"brand":{"name":"Thorne","url":"https://covenanthealthproducts.com/thorne/"},"id":23073,"can_purchase":true,"meta_description":"Try Curcumin Phytosome for natural joint support! Get free shipping on your purchase today and experience the power of this unique supplement.","category":["Brands/Thorne Supplements and Vitamins"],"AddThisServiceButtonMeta":"","main_image":{"data":"https://cdn11.bigcommerce.com/s-35tuw7jhw2/images/stencil/{:size}/products/23073/33476/curcumin-phytosome-60c-thorne__92892.1721068954.jpg?c=1","alt":"Curcumin Phytosome 1000mg 60c by Thorne"},"add_to_wishlist_url":"/wishlist.php?action=add&product_id=23073","shipping":{"calculated":true},"custom_fields":[{"id":"151108","name":"Brand","value":"<a href='/Thorne_c_3270.html'><img src=https://cdn11.bigcommerce.com/s-35tuw7jhw2/product_images/uploaded_images/brand-logos/thorne_278x90.png\" width=\"278\" height=\"90\"></a>"},{"id":"151109","name":"Questions","value":"<a href='/need-product-help'><img src=https://cdn11.bigcommerce.com/s-35tuw7jhw2/product_images/uploaded_images/need_someone_to_talk_to_250px.png\"></a><div><a href=\"/need-product-help\">Talk to an Expert</a></div>"},{"id":"151110","name":"Blog post","value":"<a href='/unlocking-wellness-curcumin-phytosome-by-thorne'><img src=https://cdn11.bigcommerce.com/s-35tuw7jhw2/product_images/uploaded_images/Click_here_for_Blog_250px.png\"></a><div><a href=\"/blog\">View Blog Post</a></div>"}],"sku":"TH-SF813-1","description":"<h3>Curcumin Phytosome by Thorne</h3>\n<p><strong>Formerly known as Meriva 500-SF, Curcumin Phytosome is a unique dietary supplement formulated by Thorne.</strong>* It may offer wide health support due to its potential effects on <a href=\"https://covenanthealthproducts.com/clinic-recommended-products/bone-joint-and-muscle-support-supplements/\">bone &amp; joint health</a>, liver health, and detoxification.*</p>\n<h3>Who May Consider Curcumin Phytosome by Thorne?</h3>\n<p><strong>Consider taking Curcumin Phytosome by Thorne if you:</strong></p>\n<ul>\n<li>experience frequent joint pain*</li>\n<li>are an athlete seeking better:</li>\n<ul>\n<li>post-workout recovery*</li>\n<li>injury management*</li>\n</ul>\n<li>are concerned about your heart health*</li>\n</ul>\n<h3>The Effects of Taking Curcumin Phytosome by Thorne</h3>\n<p><strong>Curcumin Phytosome may:</strong></p>\n<ul>\n<li>support metabolic function*</li>\n<li>promote post-workout recovery*</li>\n<li>alleviate joint pain*</li>\n<li>promote antioxidation*</li>\n<li>mitigate the causes and symptoms of a chronic inflammatory disease*</li>\n</ul>\n<p><strong>Supplements support your health but do not replace a balanced diet. </strong>Always check with your healthcare practitioner if you have doubts about a new supplement. Book a <a href=\"https://covenanthealthproducts.com/complimentary-product-consultation/\">FREE product consultation</a> to learn more about Curcumin Phytosome by Thorne.</p>\n<p><strong>Recommendation:<br /></strong>Thorne suggests taking 1-2 Curcumin Phytosome capsules two times per day, or as directed by a healthcare provider.&nbsp;</p>\n<p><strong>Serving Size:</strong> 2 Capsules<br /><strong>Servings per Container:</strong> 30 or 60</p>\n<p><strong>Amount Per Serving:</strong><br />Curcumin Phytosome (Curcuma longa extract (root) / Phosphatidylcholine complex from Sunflower) 1 g</p>\n<p><strong>Other Ingredients:</strong>&nbsp;Calcium (Citrate), Calcium Laurate, Hypromellose Capsule, Leucine, Microcrystalline Cellulose, Silicon Dioxide</p>\n<p>Turmeric is widely studied for its health-promoting properties. It has been used in Traditional Chinese Medicine, as well as Ayurvedic medicine, for more than 2,000 years. Curcumin is turmeric&rsquo;s most active component and provides numerous health benefits, including support for joint function and mobility, liver and gut health, cardiovascular function. Curcumin is also a potent antioxidant.*</p>\n<p>Because curcumin supports a healthy inflammatory response it is beneficial for anyone experiencing the bodily discomforts of life.* Curcumin can provide relief for overused muscles and joints.* In addition, maintaining a healthy inflammatory response is essential to healthy joints, muscles, brain, eyes, and blood lipids.*</p>\n<p>Thorne&rsquo;s Curcumin Phytosome, as Meriva, is the most clinically-studied curcumin on the market and, as a phytosome complex it provides superior absorption over other curcumin extracts. A human study demonstrated 29-times greater absorption of Meriva than ordinary curcumin.&nbsp;</p>\n<p><strong>Benefits of Thorne&rsquo;s Curcumin Phytosome:&nbsp;</strong></p>\n<p><strong>Joint Stiffness and Muscle Soreness:</strong></p>\n<div>\n<ul>\n<li>Reduces joint stiffness*</li>\n<li>Promotes flexibility*</li>\n<li>Provide relief from minor aches and muscle soreness*</li>\n<li>Protects muscles against exercise stress and helps reduce delayed onset muscle soreness (DOMS)*</li>\n<li>May reduce muscle injury from training or exertion*</li>\n<li>Helps protect muscle tissue from the effects of chronological age*</li>\n</ul>\n<p><strong>Healthy inflammatory response:</strong></p>\n<ul>\n<li>Helps maintain a balanced inflammatory response throughout the body, including in the joints, muscles, GI tract, liver, brain, eyes, and nerves*</li>\n</ul>\n<p><strong>Liver Support:</strong></p>\n<ul>\n<li>Promotes healthy cholesterol metabolism and up-regulation of liver enzymes*</li>\n<li>Supports maintenance of normal blood sugar*</li>\n</ul>\n<p><strong>Features of&nbsp;Thorne&rsquo;s Curcumin Phytosome:&nbsp;</strong></p>\n<ul>\n<li>The most clinically studied curcumin on the market with 29-times greater absorption than ordinary curcumin</li>\n<li>More than 30 clinical trials using Meriva &ndash; the form of curcumin extract that Thorne uses</li>\n</ul>\n<p><strong>Warnings:</strong></p>\n</div>\n<div>Curcumin has been shown to reduce the therapeutic efficacy of cyclophosphamide (Cytoxan) in animal studies. In vitro research revealed that curcumin decreased camptothecin-induced death of cultured breast cancer cells. Curcumin might also interfere with the absorption and efficacy of the chemotherapy drug irinotecan, used to treat colon cancer. The concurrent use of curcumin with these agents should be avoided.</div>\n<div>If pregnant, consult your health-care practitioner before using this Thorne product.</div>\n<p>*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.</p>\n<p><strong>References:</strong></p>\n<ol>\n<li>Honda, S., Aoki, F., Tanaka, H., et al. (2006). Effects of ingested turmeric oleoresin on glucose and lipid metabolisms in obese diabetic mice: A DNA microarray study. <em>Journal of Agricultural and Food Chemistry, 54</em>(24), 9055&ndash;9062. [PMID: 17117790]</li>\n<li>Nishiyama, T., Mae, T., Kishida, H., et al. (2005). Curcuminoids and sesquiterpenoids in turmeric (Curcuma longa L.) suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice. <em>Journal of Agricultural and Food Chemistry, 53</em>(4), 959&ndash;963. [PMID: 15713005]</li>\n<li>Antony, B., Merina, B., Iyer, V. S., et al. (2008). A pilot cross-over study to evaluate human oral bioavailability of BCM-95CG (Biocurcumax), a novel bioenhanced preparation of curcumin. <em>Indian Journal of Pharmaceutical Sciences, 70</em>(4), 445&ndash;449. [PMID: 20046768]</li>\n</ol>","tags":[],"warranty":"","price":{"without_tax":{"formatted":"$32.00","value":32,"currency":"USD"},"tax_label":"Tax"},"detail_messages":"","availability":"Usually Ships in 48 to 72 Hours","page_title":"Curcumin Phytosome by Thorne - Covenant Health Products","cart_url":"https://covenanthealthproducts.com/cart.php","max_purchase_quantity":0,"mpn":"SF813","upc":null,"options":[{"id":46800,"type":"Configurable_PickList_Set","display_name":"Size","required":true,"condition":true,"state":"variant_option","values":[{"label":"60 CT","id":160424,"data":"60 CT","selected":false},{"label":"120 CT","id":160425,"data":"120 CT","selected":false}],"partial":"set-rectangle"},{"id":41807,"type":"Configurable_PickList_Set","display_name":"Recurring Order","required":true,"condition":false,"state":"modifier","values":[{"label":"One Time Purchase","id":48845,"data":"One Time Purchase","selected":true},{"label":"Every 20 Days","id":48846,"data":"Every 20 Days","selected":false},{"label":"Every 30 Days","id":48847,"data":"Every 30 Days","selected":false},{"label":"Every 40 Days","id":48848,"data":"Every 40 Days","selected":false},{"label":"Every 45 Days","id":159647,"data":"Every 45 Days","selected":false},{"label":"Every 60 Days","id":48849,"data":"Every 60 Days","selected":false},{"label":"Every 90 Days","id":48850,"data":"Every 90 Days","selected":false},{"label":"Every 120 Days","id":48851,"data":"Every 120 Days","selected":false},{"label":"Every 180 Days","id":48852,"data":"Every 180 Days","selected":false}],"partial":"set-select"}],"related_products":[{"id":17421,"sku":"PUR-MCU1","name":"CurcumaSorb 250mg 180c","url":"https://covenanthealthproducts.com/curcumasorb-formerly-250mg-180-capsules-by-pure-encapsulations","availability":"Usually Ships in 48 to 72 Hours","rating":0,"brand":{"name":"Pure Encapsulations"},"category":["Brands/Pure Encapsulations Supplements and Vitamins"],"summary":"\nCurcumaSorb 250mg 180c by Pure Encapsulations&nbsp;\nCurcumaSorb by Pure Encapsulations is a unique and clinically studied form of curcumin designed to provide maximum support for a variety of bodily...","image":{"data":"https://cdn11.bigcommerce.com/s-35tuw7jhw2/images/stencil/{:size}/products/17421/32147/curcumasorb-250mg-180c-pure-encapsulations__96446.1711371243.jpg?c=1","alt":"CurcumaSorb 250mg 180c Pure Encapsulations"},"images":[{"data":"https://cdn11.bigcommerce.com/s-35tuw7jhw2/images/stencil/{:size}/products/17421/32147/curcumasorb-250mg-180c-pure-encapsulations__96446.1711371243.jpg?c=1","alt":"CurcumaSorb 250mg 180c Pure Encapsulations"}],"date_added":"Dec 06, 2021","pre_order":false,"show_cart_action":true,"has_options":true,"stock_level":null,"low_stock_level":null,"qty_in_cart":0,"custom_fields":[{"id":144950,"name":"Brand","value":"<a href='/Pure-Encapsulations_c_238.html'><img src=https://cdn11.bigcommerce.com/s-35tuw7jhw2/product_images/uploaded_images/brand-logos/pure-encapsulations_278x90.png\" width=\"278\" height=\"90\"></a>"},{"id":144951,"name":"Questions","value":"<a href=\"https://covenanthealthproducts.com/need-product-help\"><strong>Questions About this Product?</strong></a>"}],"num_reviews":0,"weight":{"formatted":"0.44 Ounces","value":0.44},"demo":false,"price":{"without_tax":{"currency":"USD","formatted":"$66.40","value":66.4},"tax_label":"Tax"},"add_to_wishlist_url":"/wishlist.php?action=add&product_id=17421"},{"id":17642,"sku":"TH-SF814-1","name":"Curcumin Phytosome 120c","url":"https://covenanthealthproducts.com/curcumin-phytosome-120c-thorne","availability":"Usually Ships in 48 to 72 Hours","rating":5,"brand":{"name":"Thorne"},"category":["Brands/Thorne Supplements and Vitamins"],"summary":"\nCurcumin Phytosome 120c by Thorne\n\n\n\n\nTurmeric is widely studied for its health-promoting properties. It has been used in Traditional Chinese Medicine, as well as Ayurvedic medicine, for more than...","image":{"data":"https://cdn11.bigcommerce.com/s-35tuw7jhw2/images/stencil/{:size}/products/17642/35265/Curcumin-Phytosome-1000mg-120c-Thorne__15106.1733689320.jpg?c=1","alt":"Curcumin Phytosome 120c by Thorne"},"images":[{"data":"https://cdn11.bigcommerce.com/s-35tuw7jhw2/images/stencil/{:size}/products/17642/35265/Curcumin-Phytosome-1000mg-120c-Thorne__15106.1733689320.jpg?c=1","alt":"Curcumin Phytosome 120c by Thorne"}],"date_added":"Dec 06, 2021","pre_order":false,"show_cart_action":true,"has_options":true,"stock_level":null,"low_stock_level":null,"qty_in_cart":0,"custom_fields":[{"id":151111,"name":"Brand","value":"<a href='/Thorne_c_3270.html'><img src=https://cdn11.bigcommerce.com/s-35tuw7jhw2/product_images/uploaded_images/brand-logos/thorne_278x90.png\" width=\"278\" height=\"90\"></a>"},{"id":151112,"name":"Questions","value":"<a href='/need-product-help'><img src=https://cdn11.bigcommerce.com/s-35tuw7jhw2/product_images/uploaded_images/need_someone_to_talk_to_250px.png\"></a><div><a href=\"/need-product-help\">Talk to an Expert</a></div>"},{"id":151113,"name":"Blog post","value":"<a href='/unlocking-wellness-curcumin-phytosome-by-thorne'><img src=https://cdn11.bigcommerce.com/s-35tuw7jhw2/product_images/uploaded_images/Click_here_for_Blog_250px.png\"></a><div><a href=\"/blog\">View Blog Post</a></div>"}],"num_reviews":1,"weight":{"formatted":"0.31 Ounces","value":0.31},"demo":false,"price":{"without_tax":{"currency":"USD","formatted":"$57.00","value":57},"tax_label":"Tax"},"add_to_wishlist_url":"/wishlist.php?action=add&product_id=17642"},{"id":22750,"sku":"TH-SF815","name":"Curcumin Phytosome - Sustained Release 120c","url":"https://covenanthealthproducts.com/curcumin-phytosome-sustained-release-120c-thorne","availability":"Usually Ships in 48 to 72 Hours","rating":0,"brand":{"name":"Thorne"},"category":["Brands/Thorne Supplements and Vitamins","Clinic Recommended Products","Clinic Recommended Products/Anti Inflammation Natural Supplements"],"summary":"Curcumin Phytosome - Sustained Release 120c by Thorne\nCurcumin Phytosome - Sustained Release 120c is an anti-oxidant supplement formulated by Thorne.* It is based on curcumin, an orange pigment...","image":{"data":"https://cdn11.bigcommerce.com/s-35tuw7jhw2/images/stencil/{:size}/products/22750/33480/curcumin-phytosome-120c-sustained-release-thorne__76606.1721234243.jpg?c=1","alt":"Curcumin Phytosome - Sustained Release 120c by Thorne"},"images":[{"data":"https://cdn11.bigcommerce.com/s-35tuw7jhw2/images/stencil/{:size}/products/22750/33480/curcumin-phytosome-120c-sustained-release-thorne__76606.1721234243.jpg?c=1","alt":"Curcumin Phytosome - Sustained Release 120c by Thorne"}],"date_added":"Dec 06, 2021","pre_order":false,"show_cart_action":true,"has_options":true,"stock_level":null,"low_stock_level":null,"qty_in_cart":0,"custom_fields":[{"id":148942,"name":"Brand","value":"<a href='/Thorne_c_3270.html'><img src=https://cdn11.bigcommerce.com/s-35tuw7jhw2/product_images/uploaded_images/brand-logos/thorne_278x90.png\" width=\"278\" height=\"90\"></a>"},{"id":148943,"name":"Questions","value":"<a href=\"https://covenanthealthproducts.com/need-product-help\"><strong>Questions About this Product?</strong></a>"}],"num_reviews":0,"weight":{"formatted":"0.50 Ounces","value":0.5},"demo":false,"price":{"without_tax":{"currency":"USD","formatted":"$45.00","value":45},"tax_label":"Tax"},"add_to_wishlist_url":"/wishlist.php?action=add&product_id=22750"},{"id":25061,"sku":"TH-SF814N","name":"Curcumin Phytosome - Certified for Sport 120c","url":"https://covenanthealthproducts.com/curcumin-phytosome-certified-for-sport-120c-thorne","availability":"Usually Ships in 48 to 72 Hours","rating":0,"brand":{"name":"Thorne"},"category":["Brands/Thorne Supplements and Vitamins"],"summary":"\nCurcumin Phytosome (Certified for Sport) 120c by Thorne Research\n\nTurmeric is widely studied for its health-promoting properties. It has been used in Traditional Chinese Medicine, as well as...","image":{"data":"https://cdn11.bigcommerce.com/s-35tuw7jhw2/images/stencil/{:size}/products/25061/35264/Curcumin-Phytosome-1000mg-NSF-Certified-for-Sport-120c-Thorne__01588.1733689235.jpg?c=1","alt":"Curcumin Phytosome (Certified for Sport) 120c by Thorne"},"images":[{"data":"https://cdn11.bigcommerce.com/s-35tuw7jhw2/images/stencil/{:size}/products/25061/35264/Curcumin-Phytosome-1000mg-NSF-Certified-for-Sport-120c-Thorne__01588.1733689235.jpg?c=1","alt":"Curcumin Phytosome (Certified for Sport) 120c by Thorne"}],"date_added":"Dec 06, 2021","pre_order":false,"show_cart_action":true,"has_options":true,"stock_level":null,"low_stock_level":null,"qty_in_cart":0,"custom_fields":[{"id":148940,"name":"Brand","value":"<a href='/Thorne_c_3270.html'><img src=https://cdn11.bigcommerce.com/s-35tuw7jhw2/product_images/uploaded_images/brand-logos/thorne_278x90.png\" width=\"278\" height=\"90\"></a>"},{"id":148941,"name":"Questions","value":"<a href=\"https://covenanthealthproducts.com/need-product-help\"><strong>Questions About this Product?</strong></a>"}],"num_reviews":0,"weight":{"formatted":"0.74 Ounces","value":0.74},"demo":false,"price":{"without_tax":{"currency":"USD","formatted":"$63.00","value":63},"tax_label":"Tax"},"add_to_wishlist_url":"/wishlist.php?action=add&product_id=25061"}],"shipping_messages":[],"rating":0,"reviews":{"messages":[],"captcha":"6LdWf8gSAAAAAI83aRectJhbwidegZKk8PzWBltH","total":0,"show_review_email":true,"recaptcha":{"enabled":1,"public_key":"6LdWf8gSAAAAAI83aRectJhbwidegZKk8PzWBltH","markup":"<div class=\"g-recaptcha\" data-sitekey=\"6LcjX0sbAAAAACp92-MNpx66FT4pbIWh-FTDmkkz\"></div><br/>"}},"bulk_discount_rates":[],"meta_keywords":"","show_quantity_input":1,"title":"Curcumin Phytosome","gift_wrapping_available":false,"min_purchase_quantity":1,"customizations":[],"images":[{"data":"https://cdn11.bigcommerce.com/s-35tuw7jhw2/images/stencil/{:size}/products/23073/33476/curcumin-phytosome-60c-thorne__92892.1721068954.jpg?c=1","alt":"Curcumin Phytosome 1000mg 60c by Thorne"}]}

Curcumin Phytosome

Thorne

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TH-SF813-1
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Curcumin Phytosome by Thorne

Formerly known as Meriva 500-SF, Curcumin Phytosome is a unique dietary supplement formulated by Thorne.* It may offer wide health support due to its potential effects on bone & joint health, liver health, and detoxification.*

Who May Consider Curcumin Phytosome by Thorne?

Consider taking Curcumin Phytosome by Thorne if you:

  • experience frequent joint pain*
  • are an athlete seeking better:
    • post-workout recovery*
    • injury management*
  • are concerned about your heart health*

The Effects of Taking Curcumin Phytosome by Thorne

Curcumin Phytosome may:

  • support metabolic function*
  • promote post-workout recovery*
  • alleviate joint pain*
  • promote antioxidation*
  • mitigate the causes and symptoms of a chronic inflammatory disease*

Supplements support your health but do not replace a balanced diet. Always check with your healthcare practitioner if you have doubts about a new supplement. Book a FREE product consultation to learn more about Curcumin Phytosome by Thorne.

Recommendation:
Thorne suggests taking 1-2 Curcumin Phytosome capsules two times per day, or as directed by a healthcare provider. 

Serving Size: 2 Capsules
Servings per Container: 30 or 60

Amount Per Serving:
Curcumin Phytosome (Curcuma longa extract (root) / Phosphatidylcholine complex from Sunflower) 1 g

Other Ingredients: Calcium (Citrate), Calcium Laurate, Hypromellose Capsule, Leucine, Microcrystalline Cellulose, Silicon Dioxide

Turmeric is widely studied for its health-promoting properties. It has been used in Traditional Chinese Medicine, as well as Ayurvedic medicine, for more than 2,000 years. Curcumin is turmeric’s most active component and provides numerous health benefits, including support for joint function and mobility, liver and gut health, cardiovascular function. Curcumin is also a potent antioxidant.*

Because curcumin supports a healthy inflammatory response it is beneficial for anyone experiencing the bodily discomforts of life.* Curcumin can provide relief for overused muscles and joints.* In addition, maintaining a healthy inflammatory response is essential to healthy joints, muscles, brain, eyes, and blood lipids.*

Thorne’s Curcumin Phytosome, as Meriva, is the most clinically-studied curcumin on the market and, as a phytosome complex it provides superior absorption over other curcumin extracts. A human study demonstrated 29-times greater absorption of Meriva than ordinary curcumin. 

Benefits of Thorne’s Curcumin Phytosome: 

Joint Stiffness and Muscle Soreness:

  • Reduces joint stiffness*
  • Promotes flexibility*
  • Provide relief from minor aches and muscle soreness*
  • Protects muscles against exercise stress and helps reduce delayed onset muscle soreness (DOMS)*
  • May reduce muscle injury from training or exertion*
  • Helps protect muscle tissue from the effects of chronological age*

Healthy inflammatory response:

  • Helps maintain a balanced inflammatory response throughout the body, including in the joints, muscles, GI tract, liver, brain, eyes, and nerves*

Liver Support:

  • Promotes healthy cholesterol metabolism and up-regulation of liver enzymes*
  • Supports maintenance of normal blood sugar*

Features of Thorne’s Curcumin Phytosome: 

  • The most clinically studied curcumin on the market with 29-times greater absorption than ordinary curcumin
  • More than 30 clinical trials using Meriva – the form of curcumin extract that Thorne uses

Warnings:

Curcumin has been shown to reduce the therapeutic efficacy of cyclophosphamide (Cytoxan) in animal studies. In vitro research revealed that curcumin decreased camptothecin-induced death of cultured breast cancer cells. Curcumin might also interfere with the absorption and efficacy of the chemotherapy drug irinotecan, used to treat colon cancer. The concurrent use of curcumin with these agents should be avoided.
If pregnant, consult your health-care practitioner before using this Thorne product.

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

References:

  1. Honda, S., Aoki, F., Tanaka, H., et al. (2006). Effects of ingested turmeric oleoresin on glucose and lipid metabolisms in obese diabetic mice: A DNA microarray study. Journal of Agricultural and Food Chemistry, 54(24), 9055–9062. [PMID: 17117790]
  2. Nishiyama, T., Mae, T., Kishida, H., et al. (2005). Curcuminoids and sesquiterpenoids in turmeric (Curcuma longa L.) suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice. Journal of Agricultural and Food Chemistry, 53(4), 959–963. [PMID: 15713005]
  3. Antony, B., Merina, B., Iyer, V. S., et al. (2008). A pilot cross-over study to evaluate human oral bioavailability of BCM-95CG (Biocurcumax), a novel bioenhanced preparation of curcumin. Indian Journal of Pharmaceutical Sciences, 70(4), 445–449. [PMID: 20046768]